SPA-PNN ligand for the kinetic resolution of carbocyclic and heterocyclic spiranes by asymmetric hydrogenation

Abstract The chiral carbocyclic and heterocyclic spirane scaffolds are widely present in natural products and pharmaceutical molecules. Efficient, concise, and enantioenriched synthesis of these structures is a significant objective in both academic and industrial fields. Here, we design and synthes...

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Bibliographic Details
Main Authors: Yong-Yao Li, Ka Lu, Ju-Song Yang, Xiao-Ming Zhang, Fu-Min Zhang, Yong-Qiang Tu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61360-6
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