Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations
Wounds are broadly classified into acute and chronic types, with chronic wounds being those that cannot heal within 4 to 12 weeks despite treatment. There is a growing interest in efficient and cost-effective wound healing though the drug delivery of active molecules. Natural compounds such as phyto...
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MDPI AG
2025-05-01
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| author | Panoraia I. Siafaka Androulla N. Miliotou Mehmet Evren Okur Gökçe Karaotmarlı Güven Ioannis D. Karantas Neslihan Üstündağ Okur |
| author_facet | Panoraia I. Siafaka Androulla N. Miliotou Mehmet Evren Okur Gökçe Karaotmarlı Güven Ioannis D. Karantas Neslihan Üstündağ Okur |
| author_sort | Panoraia I. Siafaka |
| collection | DOAJ |
| description | Wounds are broadly classified into acute and chronic types, with chronic wounds being those that cannot heal within 4 to 12 weeks despite treatment. There is a growing interest in efficient and cost-effective wound healing though the drug delivery of active molecules. Natural compounds such as phytochemicals, as well as synthetic molecules with antimicrobial or anti-inflammatory growth factors, can impact tissue regeneration and prevent wound infections. Nanotechnology-based systems, such as polymeric and inorganic nanoparticles and electrospun nanofibrous matrices loaded with phytochemicals, can enhance the therapeutic efficacy of active molecules through improved bioavailability and targeted delivery. This review summarizes the most current advanced applications combining phytochemicals and nanoformulations with promising wound healing potential. Various nanosystems loaded with phytochemicals have been identified, such as silver nanocarriers, zein-based nanoparticles, and various known polymers, which can be utilized to develop electrospun fibrous structures loaded with phytoremedies. Despite the incorporation of these remedies into traditional medicine for a long time, further clinical studies are essential to determine their pharmacological properties, safety concerns, and therapeutic efficacy. |
| format | Article |
| id | doaj-art-c2a8852db0c343a58cc274fb615e54e6 |
| institution | DOAJ |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-c2a8852db0c343a58cc274fb615e54e62025-08-20T03:14:35ZengMDPI AGApplied Sciences2076-34172025-05-011510541310.3390/app15105413Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and InnovationsPanoraia I. Siafaka0Androulla N. Miliotou1Mehmet Evren Okur2Gökçe Karaotmarlı Güven3Ioannis D. Karantas4Neslihan Üstündağ Okur5Department of Life Sciences, School of Sciences, Program of Pharmacy, European University Cyprus, Nicosia 2404, CyprusDepartment of Health Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia 2417, CyprusDepartment of Pharmacology, Faculty of Pharmacy, University of Health Sciences, Istanbul 34668, TurkeyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul 34688, TurkeyApostolos Loukas Medical Centre, Nicosia 2415, CyprusDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Health Sciences, Istanbul 34688, TurkeyWounds are broadly classified into acute and chronic types, with chronic wounds being those that cannot heal within 4 to 12 weeks despite treatment. There is a growing interest in efficient and cost-effective wound healing though the drug delivery of active molecules. Natural compounds such as phytochemicals, as well as synthetic molecules with antimicrobial or anti-inflammatory growth factors, can impact tissue regeneration and prevent wound infections. Nanotechnology-based systems, such as polymeric and inorganic nanoparticles and electrospun nanofibrous matrices loaded with phytochemicals, can enhance the therapeutic efficacy of active molecules through improved bioavailability and targeted delivery. This review summarizes the most current advanced applications combining phytochemicals and nanoformulations with promising wound healing potential. Various nanosystems loaded with phytochemicals have been identified, such as silver nanocarriers, zein-based nanoparticles, and various known polymers, which can be utilized to develop electrospun fibrous structures loaded with phytoremedies. Despite the incorporation of these remedies into traditional medicine for a long time, further clinical studies are essential to determine their pharmacological properties, safety concerns, and therapeutic efficacy.https://www.mdpi.com/2076-3417/15/10/5413woundhealingphytochemicalsremediesethnopharmacologynanofibers |
| spellingShingle | Panoraia I. Siafaka Androulla N. Miliotou Mehmet Evren Okur Gökçe Karaotmarlı Güven Ioannis D. Karantas Neslihan Üstündağ Okur Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations Applied Sciences wound healing phytochemicals remedies ethnopharmacology nanofibers |
| title | Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations |
| title_full | Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations |
| title_fullStr | Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations |
| title_full_unstemmed | Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations |
| title_short | Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations |
| title_sort | nanoformulations loaded with phytochemicals for combating wound infections and promoting wound healing current applications and innovations |
| topic | wound healing phytochemicals remedies ethnopharmacology nanofibers |
| url | https://www.mdpi.com/2076-3417/15/10/5413 |
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