Genome-wide association studies of Alzheimer’s disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans

Abstract Background Alzheimer’s disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. However, sample sizes in African ances...

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Main Authors:	Richard Sherva, Congcong Zhu, Rui Zhang, Jesse Mez, Richard Hauger, Victoria C. Merritt, Matthew Panizzon, J. Michael Gaziano, Vidriana Catanzaro, Gerard D. Schellenberg, Margaret Pericak-Vance, Jonathan L. Haines, Li-San Wang, Richard Mayeux, VA Million Veteran Program, Lindsay A. Farrer, Mark W. Logue
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Alzheimer’s Research & Therapy
Subjects:	Alzheimer’s disease Genome-wide association study African Ancestry RNA-sequencing Stratified
Online Access:	https://doi.org/10.1186/s13195-025-01782-y
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Genome-wide association studies of Alzheimer’s disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans

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