Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management
S. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of S. aureus infection/colonization was evaluated in 117 children as well as in their cohabitants, in order to assess the value of S. aureus characterization in predicting disease onset and severity and...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/718708 |
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| author | Chiara Pascolini JoLinda Sinagra Simone Pecetta Valentina Bordignon Alessandra De Santis Laura Cilli Viviana Cafiso Grazia Prignano Bruno Capitanio Claudio Passariello Stefania Stefani Paola Cordiali-Fei Fabrizio Ensoli |
| author_facet | Chiara Pascolini JoLinda Sinagra Simone Pecetta Valentina Bordignon Alessandra De Santis Laura Cilli Viviana Cafiso Grazia Prignano Bruno Capitanio Claudio Passariello Stefania Stefani Paola Cordiali-Fei Fabrizio Ensoli |
| author_sort | Chiara Pascolini |
| collection | DOAJ |
| description | S. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of S. aureus infection/colonization was evaluated in 117 children as well as in their cohabitants, in order to assess the value of S. aureus characterization in predicting disease onset and severity and in providing indications for prophylaxis. Results showed that children with AD as well as their cohabitants had a significantly greater incidence of S. aureus infection/colonization as compared to controls. The genetic characterization showed a virtual identity of the bacteria strains collected at different sites of the patients with those found in the cohabitants, suggesting both a direct transmission between the nasal reservoir and the lesions in the same atopic subject and a risk for reinfection within family cohabitants. These data stress the need of preliminary laboratory assessment and posttherapy control in both AD patients and their close contacts for effective S. aureus eradication. |
| format | Article |
| id | doaj-art-c2a43624951e4bfabc4d78c8d085886f |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-c2a43624951e4bfabc4d78c8d085886f2025-08-20T02:18:59ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/718708718708Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical ManagementChiara Pascolini0JoLinda Sinagra1Simone Pecetta2Valentina Bordignon3Alessandra De Santis4Laura Cilli5Viviana Cafiso6Grazia Prignano7Bruno Capitanio8Claudio Passariello9Stefania Stefani10Paola Cordiali-Fei11Fabrizio Ensoli12Clinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyDepartment of Public Health and Infectious Diseases, University La Sapienza, 00185 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyDepartment of Microbiology, University of Catania, 95124 Catania, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyDepartment of Public Health and Infectious Diseases, University La Sapienza, 00185 Rome, ItalyDepartment of Microbiology, University of Catania, 95124 Catania, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyClinical Pathology and Microbiology Laboratory and Pediatric Dermatology Division, San Gallicano Dermatology Institute, 00144 Rome, ItalyS. aureus represents a critical cofactor in atopic dermatitis (AD). In this paper, the prevalence of S. aureus infection/colonization was evaluated in 117 children as well as in their cohabitants, in order to assess the value of S. aureus characterization in predicting disease onset and severity and in providing indications for prophylaxis. Results showed that children with AD as well as their cohabitants had a significantly greater incidence of S. aureus infection/colonization as compared to controls. The genetic characterization showed a virtual identity of the bacteria strains collected at different sites of the patients with those found in the cohabitants, suggesting both a direct transmission between the nasal reservoir and the lesions in the same atopic subject and a risk for reinfection within family cohabitants. These data stress the need of preliminary laboratory assessment and posttherapy control in both AD patients and their close contacts for effective S. aureus eradication.http://dx.doi.org/10.1155/2011/718708 |
| spellingShingle | Chiara Pascolini JoLinda Sinagra Simone Pecetta Valentina Bordignon Alessandra De Santis Laura Cilli Viviana Cafiso Grazia Prignano Bruno Capitanio Claudio Passariello Stefania Stefani Paola Cordiali-Fei Fabrizio Ensoli Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management Clinical and Developmental Immunology |
| title | Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management |
| title_full | Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management |
| title_fullStr | Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management |
| title_full_unstemmed | Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management |
| title_short | Molecular and Immunological Characterization of Staphylococcus aureus in Pediatric Atopic Dermatitis: Implications for Prophylaxis and Clinical Management |
| title_sort | molecular and immunological characterization of staphylococcus aureus in pediatric atopic dermatitis implications for prophylaxis and clinical management |
| url | http://dx.doi.org/10.1155/2011/718708 |
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