Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications
This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic target...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/11/2599 |
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| author | Tatiana Zubareva Ekaterina Mironova Anna Panfilova Yulia Krylova Gianluigi Mazzoccoli Maria Greta Pia Marasco Igor Kvetnoy Peter Yablonsky |
| author_facet | Tatiana Zubareva Ekaterina Mironova Anna Panfilova Yulia Krylova Gianluigi Mazzoccoli Maria Greta Pia Marasco Igor Kvetnoy Peter Yablonsky |
| author_sort | Tatiana Zubareva |
| collection | DOAJ |
| description | This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic targets. The review particularly focuses on the involvement of gap junction connexins and hemichannels in the transfer of calcium ions, metabolite molecules, ATP, and mitochondria through the cell membrane. Various disorders in the regulation of intercellular communication can heavily contribute to the pathogenesis of multiple diseases, including respiratory system diseases. A deeper understanding of molecular mechanisms underlying the activities of various connexins in gap junction channels will enable the prospective development of therapeutic approaches by either inhibiting or stimulating the activities of a certain connexin, while considering its critical functions in intercellular communications on the whole. |
| format | Article |
| id | doaj-art-c2a3a314faff47ae9638f85c2dac3818 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-c2a3a314faff47ae9638f85c2dac38182025-08-20T02:07:59ZengMDPI AGBiomedicines2227-90592024-11-011211259910.3390/biomedicines12112599Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular CommunicationsTatiana Zubareva0Ekaterina Mironova1Anna Panfilova2Yulia Krylova3Gianluigi Mazzoccoli4Maria Greta Pia Marasco5Igor Kvetnoy6Peter Yablonsky7Department of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaDepartment of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaDepartment of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaDepartment of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaChronobiologi Laboratory, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, ItalyChronobiologi Laboratory, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, 71013 San Giovanni Rotondo, ItalyDepartment of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaDepartment of Translational Biomedicine, Saint-Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, RussiaThis article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic targets. The review particularly focuses on the involvement of gap junction connexins and hemichannels in the transfer of calcium ions, metabolite molecules, ATP, and mitochondria through the cell membrane. Various disorders in the regulation of intercellular communication can heavily contribute to the pathogenesis of multiple diseases, including respiratory system diseases. A deeper understanding of molecular mechanisms underlying the activities of various connexins in gap junction channels will enable the prospective development of therapeutic approaches by either inhibiting or stimulating the activities of a certain connexin, while considering its critical functions in intercellular communications on the whole.https://www.mdpi.com/2227-9059/12/11/2599connexinCx43Cx37connexongap junctionintercellular communications |
| spellingShingle | Tatiana Zubareva Ekaterina Mironova Anna Panfilova Yulia Krylova Gianluigi Mazzoccoli Maria Greta Pia Marasco Igor Kvetnoy Peter Yablonsky Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications Biomedicines connexin Cx43 Cx37 connexon gap junction intercellular communications |
| title | Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications |
| title_full | Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications |
| title_fullStr | Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications |
| title_full_unstemmed | Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications |
| title_short | Connexins and Aging-Associated Respiratory Disorders: The Role in Intercellular Communications |
| title_sort | connexins and aging associated respiratory disorders the role in intercellular communications |
| topic | connexin Cx43 Cx37 connexon gap junction intercellular communications |
| url | https://www.mdpi.com/2227-9059/12/11/2599 |
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