Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolismResearch in context

Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolismResearch in context

Summary: Background: The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD), and exercise training can reduce the risk of AD. Two early pathologies of AD are degradation of tight junctions between brain microvascular endothelial cells (BMEC) and brain glucose hypo...

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Bibliographic Details
Main Authors: Callie M. Weber, Bilal Moiz, Gabriel S. Pena, Marzyeh Kheradmand, Brooke Wunderler, Claire Kettula, Gurneet S. Sangha, J. Carson Smith, Alisa Morss Clyne
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:EBioMedicine
Subjects:
Blood-brain barrier
Alzheimer's disease
Glucose metabolism
APOE genotype
Exercise training
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424005231
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