Roflumilast reduces the number of lung adenocarcinomas, inflammation, and emphysema in a smoking-induced mouse model

Roflumilast reduces the number of lung adenocarcinomas, inflammation, and emphysema in a smoking-induced mouse model

Abstract Background The prognosis of lung cancer complicated by chronic obstructive pulmonary disease is poor, and effective prophylactic agents have not been established. Given that inflammation is a shared pathogenic mechanism of both diseases, we aimed to evaluate the efficacy of roflumilast, a n...

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Bibliographic Details
Main Authors: Kaori Sakurai, Shingo Nakayama, Shotaro Chubachi, Shiro Otake, Takashi Shimada, Hidehiro Irie, Akihiro Tsutsumi, Naofumi Kameyama, Ahmed E. Hegab, Masayuki Shimoda, Junko Hamamoto, Hideki Terai, Hiroyuki Yasuda, Yae Kanai, Koichi Fukunaga
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pulmonary Medicine
Subjects:
Chronic obstructive pulmonary disease
Lung neoplasm
PDE4 inhibitor
Smoking
Chemoprevention
Online Access:https://doi.org/10.1186/s12890-025-03730-w
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