Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats

Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats

Abstract Background Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory function via a neuroinflammatory mechanism. However, the degree to which the...

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Main Authors: Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Immunity & Ageing
Subjects:
Cytokines
High fat diet
Gut microbiome
Online Access:https://doi.org/10.1186/s12979-024-00496-3
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