Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway

Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway

BackgroundMethotrexate (MTX), a folate antagonist, is widely used in the treatment of tumors and autoimmune diseases such as rheumatoid arthritis (RA), due to its antiproliferative, antimetabolic, and potent anti-inflammatory properties. However, high-dose or long-term use of MTX can result in toxic...

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Main Authors: Wu Chen, Min Chen, Dian-Ming Li, Wei-Man Shi, Min Zhang, Zhi-Yu Li, Lin Huang, Cheng-Ping Wen, Qiao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
yunpi jiedu tongluo qushi decoction
methotrexate
oxidative stress
cell apoptosis
reproductive damage
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1626955/full
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