Does Dexamphetamine Cause Addiction? A Narrative Review
Dexamphetamine (DEX) is widely used in treatments, but concerns persist about its potential for addiction. This review aimed to assess the risks of DEX addiction by examining the existing literature. Originally planned as a systematic review, it was adjusted to a narrative review due to a lack of qu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Psychoactives |
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| Online Access: | https://www.mdpi.com/2813-1851/4/1/3 |
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| author | Hazer Khalifa Emily J. Hibbert Natalie Gauci Alison Poulton |
| author_facet | Hazer Khalifa Emily J. Hibbert Natalie Gauci Alison Poulton |
| author_sort | Hazer Khalifa |
| collection | DOAJ |
| description | Dexamphetamine (DEX) is widely used in treatments, but concerns persist about its potential for addiction. This review aimed to assess the risks of DEX addiction by examining the existing literature. Originally planned as a systematic review, it was adjusted to a narrative review due to a lack of qualifying studies. A search of the literature on addiction to DEX was conducted on three databases including PubMed, Scopus, and Embase. Seven articles consisting of three reviews and four papers with original data were identified and reviewed. In total, four poorly documented cases of possible DEX addiction were found. The commonly cited papers on prescription DEX addiction did not hold up to scrutiny. Overall, the evidence that DEX is addictive is limited and inconclusive, highlighting the need for more rigorous research to clarify its true addiction risk. |
| format | Article |
| id | doaj-art-c28715f3da9f4068b0d5c16b9d838e65 |
| institution | DOAJ |
| issn | 2813-1851 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Psychoactives |
| spelling | doaj-art-c28715f3da9f4068b0d5c16b9d838e652025-08-20T02:43:06ZengMDPI AGPsychoactives2813-18512025-02-0141310.3390/psychoactives4010003Does Dexamphetamine Cause Addiction? A Narrative ReviewHazer Khalifa0Emily J. Hibbert1Natalie Gauci2Alison Poulton3Nepean Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, AustraliaNepean Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, AustraliaNepean Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, AustraliaNepean Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, AustraliaDexamphetamine (DEX) is widely used in treatments, but concerns persist about its potential for addiction. This review aimed to assess the risks of DEX addiction by examining the existing literature. Originally planned as a systematic review, it was adjusted to a narrative review due to a lack of qualifying studies. A search of the literature on addiction to DEX was conducted on three databases including PubMed, Scopus, and Embase. Seven articles consisting of three reviews and four papers with original data were identified and reviewed. In total, four poorly documented cases of possible DEX addiction were found. The commonly cited papers on prescription DEX addiction did not hold up to scrutiny. Overall, the evidence that DEX is addictive is limited and inconclusive, highlighting the need for more rigorous research to clarify its true addiction risk.https://www.mdpi.com/2813-1851/4/1/3dexamphetamineaddictiondependencesubstance use disorderstimulantspsychostimulants |
| spellingShingle | Hazer Khalifa Emily J. Hibbert Natalie Gauci Alison Poulton Does Dexamphetamine Cause Addiction? A Narrative Review Psychoactives dexamphetamine addiction dependence substance use disorder stimulants psychostimulants |
| title | Does Dexamphetamine Cause Addiction? A Narrative Review |
| title_full | Does Dexamphetamine Cause Addiction? A Narrative Review |
| title_fullStr | Does Dexamphetamine Cause Addiction? A Narrative Review |
| title_full_unstemmed | Does Dexamphetamine Cause Addiction? A Narrative Review |
| title_short | Does Dexamphetamine Cause Addiction? A Narrative Review |
| title_sort | does dexamphetamine cause addiction a narrative review |
| topic | dexamphetamine addiction dependence substance use disorder stimulants psychostimulants |
| url | https://www.mdpi.com/2813-1851/4/1/3 |
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