A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications
Thermosensitive hydrogels undergo reversible sol-gel phase transitions in response to changes in temperature. Owing to their excellent biocompatibility, mild reaction conditions, and controllable gelation properties, these hydrogels represent a promising class of biomaterials suitable for minimally...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/7/544 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849246428389441536 |
|---|---|
| author | Tianyang Lv Yuzhu Chen Ning Li Xiaoyu Liao Yumin Heng Yayuan Guo Kaijin Hu |
| author_facet | Tianyang Lv Yuzhu Chen Ning Li Xiaoyu Liao Yumin Heng Yayuan Guo Kaijin Hu |
| author_sort | Tianyang Lv |
| collection | DOAJ |
| description | Thermosensitive hydrogels undergo reversible sol-gel phase transitions in response to changes in temperature. Owing to their excellent biocompatibility, mild reaction conditions, and controllable gelation properties, these hydrogels represent a promising class of biomaterials suitable for minimally invasive treatment systems in diverse biomedical applications. This review systematically summarizes the gelation mechanisms of thermosensitive hydrogels and optimization strategies to enhance their performance for broader application requirements. In particular, we highlight recent advances in injectable thermosensitive hydrogels as a carrier within stem cells, bioactive substances, and drug delivery for treating various tissue defects and diseases involving bone, cartilage, and other tissues. Furthermore, we propose challenges and directions for the future development of thermosensitive hydrogels. These insights provide new ideas for researchers to explore novel thermosensitive hydrogels for tissue repair and disease treatment. |
| format | Article |
| id | doaj-art-c286e9af5eb048a29e00f0cf79840c77 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-c286e9af5eb048a29e00f0cf79840c772025-08-20T03:58:30ZengMDPI AGGels2310-28612025-07-0111754410.3390/gels11070544A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and ApplicationsTianyang Lv0Yuzhu Chen1Ning Li2Xiaoyu Liao3Yumin Heng4Yayuan Guo5Kaijin Hu6Xian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaXian Key Laboratory for the Prevention and Control of Stomatognathic System Disorders, School of Stomatology, Xi’an Medical University, Xi’an 710021, ChinaThermosensitive hydrogels undergo reversible sol-gel phase transitions in response to changes in temperature. Owing to their excellent biocompatibility, mild reaction conditions, and controllable gelation properties, these hydrogels represent a promising class of biomaterials suitable for minimally invasive treatment systems in diverse biomedical applications. This review systematically summarizes the gelation mechanisms of thermosensitive hydrogels and optimization strategies to enhance their performance for broader application requirements. In particular, we highlight recent advances in injectable thermosensitive hydrogels as a carrier within stem cells, bioactive substances, and drug delivery for treating various tissue defects and diseases involving bone, cartilage, and other tissues. Furthermore, we propose challenges and directions for the future development of thermosensitive hydrogels. These insights provide new ideas for researchers to explore novel thermosensitive hydrogels for tissue repair and disease treatment.https://www.mdpi.com/2310-2861/11/7/544thermosensitive hydrogelsmechanismoptimization strategydelivery systemtissue engineering |
| spellingShingle | Tianyang Lv Yuzhu Chen Ning Li Xiaoyu Liao Yumin Heng Yayuan Guo Kaijin Hu A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications Gels thermosensitive hydrogels mechanism optimization strategy delivery system tissue engineering |
| title | A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications |
| title_full | A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications |
| title_fullStr | A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications |
| title_full_unstemmed | A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications |
| title_short | A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications |
| title_sort | comprehensive review of thermosensitive hydrogels mechanism optimization strategies and applications |
| topic | thermosensitive hydrogels mechanism optimization strategy delivery system tissue engineering |
| url | https://www.mdpi.com/2310-2861/11/7/544 |
| work_keys_str_mv | AT tianyanglv acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yuzhuchen acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT ningli acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT xiaoyuliao acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yuminheng acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yayuanguo acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT kaijinhu acomprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT tianyanglv comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yuzhuchen comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT ningli comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT xiaoyuliao comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yuminheng comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT yayuanguo comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications AT kaijinhu comprehensivereviewofthermosensitivehydrogelsmechanismoptimizationstrategiesandapplications |