Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms
Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. Pathogens are primarily removed by direct opsonisation following the recognition of cell surface carbohydrates...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/3205072 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552387321004032 |
|---|---|
| author | Stefan Bidula Darren W. Sexton Silke Schelenz |
| author_facet | Stefan Bidula Darren W. Sexton Silke Schelenz |
| author_sort | Stefan Bidula |
| collection | DOAJ |
| description | Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. Pathogens are primarily removed by direct opsonisation following the recognition of cell surface carbohydrates and other immunostimulatory molecules or via the activation of the lectin complement pathway, which results in the deposition of C3b and the recruitment of phagocytes. In recent years, there have been a number of studies implicating ficolins in the recognition and removal of numerous bacterial, viral, fungal, and parasitic pathogens. Moreover, there has been expanding evidence highlighting that mutations within these key immune proteins, or the possession of particular haplotypes, enhance susceptibility to colonization by pathogens and dysfunctional immune responses. This review will therefore encompass previous knowledge on the role of ficolins in the recognition of bacterial and viral pathogens, while acknowledging the recent advances in the immune response to fungal and parasitic infections. Additionally, we will explore the various genetic susceptibility factors that predispose individuals to infection. |
| format | Article |
| id | doaj-art-c27e74258e54480ba1c65df8cc1011a7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c27e74258e54480ba1c65df8cc1011a72025-02-03T05:58:54ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/32050723205072Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide PolymorphismsStefan Bidula0Darren W. Sexton1Silke Schelenz2School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UKSchool of Pharmacy and Biomolecular Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UKDepartment of Microbiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UKFicolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. Pathogens are primarily removed by direct opsonisation following the recognition of cell surface carbohydrates and other immunostimulatory molecules or via the activation of the lectin complement pathway, which results in the deposition of C3b and the recruitment of phagocytes. In recent years, there have been a number of studies implicating ficolins in the recognition and removal of numerous bacterial, viral, fungal, and parasitic pathogens. Moreover, there has been expanding evidence highlighting that mutations within these key immune proteins, or the possession of particular haplotypes, enhance susceptibility to colonization by pathogens and dysfunctional immune responses. This review will therefore encompass previous knowledge on the role of ficolins in the recognition of bacterial and viral pathogens, while acknowledging the recent advances in the immune response to fungal and parasitic infections. Additionally, we will explore the various genetic susceptibility factors that predispose individuals to infection.http://dx.doi.org/10.1155/2019/3205072 |
| spellingShingle | Stefan Bidula Darren W. Sexton Silke Schelenz Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms Journal of Immunology Research |
| title | Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms |
| title_full | Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms |
| title_fullStr | Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms |
| title_full_unstemmed | Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms |
| title_short | Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms |
| title_sort | ficolins and the recognition of pathogenic microorganisms an overview of the innate immune response and contribution of single nucleotide polymorphisms |
| url | http://dx.doi.org/10.1155/2019/3205072 |
| work_keys_str_mv | AT stefanbidula ficolinsandtherecognitionofpathogenicmicroorganismsanoverviewoftheinnateimmuneresponseandcontributionofsinglenucleotidepolymorphisms AT darrenwsexton ficolinsandtherecognitionofpathogenicmicroorganismsanoverviewoftheinnateimmuneresponseandcontributionofsinglenucleotidepolymorphisms AT silkeschelenz ficolinsandtherecognitionofpathogenicmicroorganismsanoverviewoftheinnateimmuneresponseandcontributionofsinglenucleotidepolymorphisms |