Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye
Objective To investigate quantitative changes in iris blood flow after first-eye and second-eye cataract surgeries, and their correlation with increased pain in the second eye.Methods and analysis In this prospective study, 88 eyes of 44 participants who underwent uneventful cataract surgery were fo...
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BMJ Publishing Group
2025-08-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/10/1/e002162.full |
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| author | Yi Lu Xiangjia Zhu Wenwen He Jiao Qi Yu Du Jiaqi Meng Jitong Zhou Kaiwen Cheng Yuxi Chen Yunqian Yao |
| author_facet | Yi Lu Xiangjia Zhu Wenwen He Jiao Qi Yu Du Jiaqi Meng Jitong Zhou Kaiwen Cheng Yuxi Chen Yunqian Yao |
| author_sort | Yi Lu |
| collection | DOAJ |
| description | Objective To investigate quantitative changes in iris blood flow after first-eye and second-eye cataract surgeries, and their correlation with increased pain in the second eye.Methods and analysis In this prospective study, 88 eyes of 44 participants who underwent uneventful cataract surgery were followed up at enrolment, 1 day before, and 1 day, 1 week and 1 month after each eye surgery. Iris blood flow was quantified by a swept-source optical coherence tomography angiography and intraoperative pain was evaluated. Participants were divided into three groups according to time intervals between two eye surgeries: ≥1 to <2 weeks (short interval), ≥2 to ≤4 weeks (medium interval) and greater than 4 weeks (long interval).Results The second eye experienced two significant increases in iris blood flow following cataract surgery: one after the first eye and the other after its own, with the latter being significantly higher than the increase observed in the operated eye after the first surgery (p<0.05). Additionally, the second eye showed higher iris blood flow density in the short interval group compared with the long and medium at specific time points (p<0.05). The bilateral pain index difference positively correlated with second eye iris blood flow density (p<0.05) and was significantly greater in the short interval group than the long interval group (p<0.05).Conclusions Iris blood flow increased in the second-operated eye post surgery compared with the first eye, which may correlate to second-eye pain. However, due to the variability in individual pain perception, a larger sample size is needed to prospectively validate our findings to improve their generalisability.Trial registration number NCT02182921. |
| format | Article |
| id | doaj-art-c27cb84c4c384d5f91f67929651a7200 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-c27cb84c4c384d5f91f67929651a72002025-08-21T02:35:15ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692025-08-0110110.1136/bmjophth-2025-002162Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eyeYi Lu0Xiangjia Zhu1Wenwen He2Jiao Qi3Yu Du4Jiaqi Meng5Jitong Zhou6Kaiwen Cheng7Yuxi Chen8Yunqian Yao92 NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China3 Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China4 Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China2 NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China1 Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, ChinaObjective To investigate quantitative changes in iris blood flow after first-eye and second-eye cataract surgeries, and their correlation with increased pain in the second eye.Methods and analysis In this prospective study, 88 eyes of 44 participants who underwent uneventful cataract surgery were followed up at enrolment, 1 day before, and 1 day, 1 week and 1 month after each eye surgery. Iris blood flow was quantified by a swept-source optical coherence tomography angiography and intraoperative pain was evaluated. Participants were divided into three groups according to time intervals between two eye surgeries: ≥1 to <2 weeks (short interval), ≥2 to ≤4 weeks (medium interval) and greater than 4 weeks (long interval).Results The second eye experienced two significant increases in iris blood flow following cataract surgery: one after the first eye and the other after its own, with the latter being significantly higher than the increase observed in the operated eye after the first surgery (p<0.05). Additionally, the second eye showed higher iris blood flow density in the short interval group compared with the long and medium at specific time points (p<0.05). The bilateral pain index difference positively correlated with second eye iris blood flow density (p<0.05) and was significantly greater in the short interval group than the long interval group (p<0.05).Conclusions Iris blood flow increased in the second-operated eye post surgery compared with the first eye, which may correlate to second-eye pain. However, due to the variability in individual pain perception, a larger sample size is needed to prospectively validate our findings to improve their generalisability.Trial registration number NCT02182921.https://bmjophth.bmj.com/content/10/1/e002162.full |
| spellingShingle | Yi Lu Xiangjia Zhu Wenwen He Jiao Qi Yu Du Jiaqi Meng Jitong Zhou Kaiwen Cheng Yuxi Chen Yunqian Yao Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye BMJ Open Ophthalmology |
| title | Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye |
| title_full | Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye |
| title_fullStr | Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye |
| title_full_unstemmed | Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye |
| title_short | Comparative analysis of iris blood flow after first-eye and second-eye cataract surgeries: insights into increased pain perception in the second eye |
| title_sort | comparative analysis of iris blood flow after first eye and second eye cataract surgeries insights into increased pain perception in the second eye |
| url | https://bmjophth.bmj.com/content/10/1/e002162.full |
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