Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics
The association between embryo morphokinetics and its developmental competence is well documented. For instance, early cleaved embryos are more competent in developing to blastocysts, whereas the proportion of abnormally cleaved embryos that further developed to blastocysts is low. Numerous factors,...
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2024-10-01
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| Series: | Journal of Xenobiotics |
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| author | Dorit Kalo Shira Yaacobi-Artzi Shir Manovich Ariel Michaelov Alisa Komsky-Elbaz Zvi Roth |
| author_facet | Dorit Kalo Shira Yaacobi-Artzi Shir Manovich Ariel Michaelov Alisa Komsky-Elbaz Zvi Roth |
| author_sort | Dorit Kalo |
| collection | DOAJ |
| description | The association between embryo morphokinetics and its developmental competence is well documented. For instance, early cleaved embryos are more competent in developing to blastocysts, whereas the proportion of abnormally cleaved embryos that further developed to blastocysts is low. Numerous factors, such as the parental age, lifestyle, health, and smoking habits have been reported to affect the embryo morphokinetics and, consequently, its development. However, less is known about the effect of environmental stressors on embryo morphokinetics. The current review discusses the effect of the most concerning environmental stressors on embryo morphokinetics. These stresses include heat stress and human-made chemicals such as phthalates (e.g., bis-(2-ethylhexyl phthalate, dibutyl phthalate, dimethyl phthalate, and their primary metabolites), herbicides (e.g., diaminochlorotriazine, the primary metabolite of atrazine), pharmaceutical compounds (e.g., carbamazepine, nocodazole) and pro-oxidant agents (cumene hydroperoxide, Triton X-100), as well as naturally occurring toxins such as mycotoxin (e.g., aflatoxin B1 and its metabolite, and ochratoxin A). In addition, this review discusses the effect of ionizing or non-ionizing radiation and viral infections (e.g., SARS-CoV-2, papillomavirus). Finally, it points out some potential mechanisms that underlie the impairment of embryo morphokinetics, and it suggests protective compounds, mainly the supplementation of antioxidants to improve the morphokinetics, and consequently, the embryo developmental competence. |
| format | Article |
| id | doaj-art-c27a1bb324dc4ea7b02c8732ec076133 |
| institution | DOAJ |
| issn | 2039-4705 2039-4713 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Journal of Xenobiotics |
| spelling | doaj-art-c27a1bb324dc4ea7b02c8732ec0761332025-08-20T02:50:53ZengMDPI AGJournal of Xenobiotics2039-47052039-47132024-10-011441613163710.3390/jox14040087Environmental Stress-Induced Alterations in Embryo Developmental MorphokineticsDorit Kalo0Shira Yaacobi-Artzi1Shir Manovich2Ariel Michaelov3Alisa Komsky-Elbaz4Zvi Roth5Department of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelDepartment of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelDepartment of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelDepartment of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelDepartment of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelDepartment of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot 7610001, IsraelThe association between embryo morphokinetics and its developmental competence is well documented. For instance, early cleaved embryos are more competent in developing to blastocysts, whereas the proportion of abnormally cleaved embryos that further developed to blastocysts is low. Numerous factors, such as the parental age, lifestyle, health, and smoking habits have been reported to affect the embryo morphokinetics and, consequently, its development. However, less is known about the effect of environmental stressors on embryo morphokinetics. The current review discusses the effect of the most concerning environmental stressors on embryo morphokinetics. These stresses include heat stress and human-made chemicals such as phthalates (e.g., bis-(2-ethylhexyl phthalate, dibutyl phthalate, dimethyl phthalate, and their primary metabolites), herbicides (e.g., diaminochlorotriazine, the primary metabolite of atrazine), pharmaceutical compounds (e.g., carbamazepine, nocodazole) and pro-oxidant agents (cumene hydroperoxide, Triton X-100), as well as naturally occurring toxins such as mycotoxin (e.g., aflatoxin B1 and its metabolite, and ochratoxin A). In addition, this review discusses the effect of ionizing or non-ionizing radiation and viral infections (e.g., SARS-CoV-2, papillomavirus). Finally, it points out some potential mechanisms that underlie the impairment of embryo morphokinetics, and it suggests protective compounds, mainly the supplementation of antioxidants to improve the morphokinetics, and consequently, the embryo developmental competence.https://www.mdpi.com/2039-4713/14/4/87embryo morphokineticsenvironmental stressorstime-lapse system |
| spellingShingle | Dorit Kalo Shira Yaacobi-Artzi Shir Manovich Ariel Michaelov Alisa Komsky-Elbaz Zvi Roth Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics Journal of Xenobiotics embryo morphokinetics environmental stressors time-lapse system |
| title | Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics |
| title_full | Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics |
| title_fullStr | Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics |
| title_full_unstemmed | Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics |
| title_short | Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics |
| title_sort | environmental stress induced alterations in embryo developmental morphokinetics |
| topic | embryo morphokinetics environmental stressors time-lapse system |
| url | https://www.mdpi.com/2039-4713/14/4/87 |
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