Effect of active oxygen gel on the clinical parameters of MRONJ
Purpose: The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ. Methods: Using split-mouth study design, twelve Wistar rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / k...
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905224002554 |
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| author | Bruna Cristina de Cristo Hassan Yousef Saleh Suyany Weiss Aline Sebastiani Mohammed Elsalanty Rafaela Scariot Tatiana Miranda Deliberador |
| author_facet | Bruna Cristina de Cristo Hassan Yousef Saleh Suyany Weiss Aline Sebastiani Mohammed Elsalanty Rafaela Scariot Tatiana Miranda Deliberador |
| author_sort | Bruna Cristina de Cristo |
| collection | DOAJ |
| description | Purpose: The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ. Methods: Using split-mouth study design, twelve Wistar rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / kg body weight in PBS) for 8 weeks. Then, the animals underwent surgery to remove the first and second right and left mandibular molars to induce osteonecrosis. The animals received topical application of oxygen gel (blue®m) on the right-side extraction site (Group T) 3 times a week until euthanasia after 6 weeks, with no intervention on the left side (Group C). The clinical parameters analyzed included the presence and dimension of bone exposure, suppuration and epithelialization. Results: Statistical analysis using chi-square and Mann-Whitney test (p value < 0.05) demonstrated that group C had more severe signs of MRONJ at euthanasia than in the group T. Conclusion: Within the limitations of this pilot study, we can conclude that the application of active oxygen gel could be beneficial in the prevention of MRONJ. |
| format | Article |
| id | doaj-art-c273bde2e8a443bba896cca8c57c79f3 |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-c273bde2e8a443bba896cca8c57c79f32025-08-20T03:04:51ZengSpringerSaudi Dental Journal1013-90522024-11-0136111456145810.1016/j.sdentj.2024.09.003Effect of active oxygen gel on the clinical parameters of MRONJBruna Cristina de Cristo0Hassan Yousef Saleh1Suyany Weiss2Aline Sebastiani3Mohammed Elsalanty4Rafaela Scariot5Tatiana Miranda Deliberador6Universidade Positivo, Curitiba, BrazilLatin American Institute of Dental Research and Education- ILAPEO, Curitiba, BrazilUniversidade Positivo, Curitiba, Brazil; Cleft Lip and Palate Integral Care Center, Hospital do Trabalhador, Curitiba, BrazilDepartment of Stomatology, Surgery and Bucomaxillofacial Traumatology, Federal University of Parana, Curitiba, BrazilDepartment of Medical Anatomical Sciences, College of Osteopathic Medicine of the Pacific, Pomona, CA, USADepartment of Stomatology, Surgery and Bucomaxillofacial Traumatology, Federal University of Parana, Curitiba, BrazilLatin American Institute of Dental Research and Education- ILAPEO, Curitiba, Brazil; Departament of Periodontics, Saveetha Dental College, Chennai, India; Corresponding author at: Rua Eduardo Sprada, 3439, casa 10, Curitiba, PR, Brazil.Purpose: The aim of this work was to evaluate the effectiveness of a gel with active oxygen in the prevention of MRONJ. Methods: Using split-mouth study design, twelve Wistar rats were used, females (n = 6) and males (n = 6). All rats received a weekly intravenous injection of zoledronate (80 μg / kg body weight in PBS) for 8 weeks. Then, the animals underwent surgery to remove the first and second right and left mandibular molars to induce osteonecrosis. The animals received topical application of oxygen gel (blue®m) on the right-side extraction site (Group T) 3 times a week until euthanasia after 6 weeks, with no intervention on the left side (Group C). The clinical parameters analyzed included the presence and dimension of bone exposure, suppuration and epithelialization. Results: Statistical analysis using chi-square and Mann-Whitney test (p value < 0.05) demonstrated that group C had more severe signs of MRONJ at euthanasia than in the group T. Conclusion: Within the limitations of this pilot study, we can conclude that the application of active oxygen gel could be beneficial in the prevention of MRONJ.http://www.sciencedirect.com/science/article/pii/S1013905224002554OsteonecrosisBisphosphonatesOxygen |
| spellingShingle | Bruna Cristina de Cristo Hassan Yousef Saleh Suyany Weiss Aline Sebastiani Mohammed Elsalanty Rafaela Scariot Tatiana Miranda Deliberador Effect of active oxygen gel on the clinical parameters of MRONJ Saudi Dental Journal Osteonecrosis Bisphosphonates Oxygen |
| title | Effect of active oxygen gel on the clinical parameters of MRONJ |
| title_full | Effect of active oxygen gel on the clinical parameters of MRONJ |
| title_fullStr | Effect of active oxygen gel on the clinical parameters of MRONJ |
| title_full_unstemmed | Effect of active oxygen gel on the clinical parameters of MRONJ |
| title_short | Effect of active oxygen gel on the clinical parameters of MRONJ |
| title_sort | effect of active oxygen gel on the clinical parameters of mronj |
| topic | Osteonecrosis Bisphosphonates Oxygen |
| url | http://www.sciencedirect.com/science/article/pii/S1013905224002554 |
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