Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients
Abstract Background Cardiac and non-cardiac comorbidities are highly prevalent in patients with heart failure (HF). The aim of the present study was to describe their selective impact on in-hospital outcomes (length of hospitalization and mortality) of HF patients hospitalized in an Internal Medicin...
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BMC
2025-05-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-025-06002-8 |
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| author | Veronica Murru Elena Belfiori Alessandro Sestu Andrea Casanova Carla Serra Angelo Scuteri |
| author_facet | Veronica Murru Elena Belfiori Alessandro Sestu Andrea Casanova Carla Serra Angelo Scuteri |
| author_sort | Veronica Murru |
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| description | Abstract Background Cardiac and non-cardiac comorbidities are highly prevalent in patients with heart failure (HF). The aim of the present study was to describe their selective impact on in-hospital outcomes (length of hospitalization and mortality) of HF patients hospitalized in an Internal Medicine Unit. Methods Between January 2017 and December 2022, 12,435 (6146 F, 6289 M) inpatients were hospitalized in our Internal Medicine Unit. HF was defined according to the International Statistical Classification of Diseases and Related Health Problems (ICD) version 9 codes 428, 402.01, 402.11, 402.91, 404.11, 404.13, 404.91, 404.93. Patients were classified by burden of overall, cardiac, and of non-cardiac comorbidities (0, 1, 2, 3 +). Multivariable regression models were used to assess associations between comorbidity burden and length of stay (linear regression) or in-hospital mortality (logistic regression). Results HF patients (1481, or 11.9% of all hospitalizations during the observation period) had on average comorbidity count of 1.6. An increasing number of comorbidities was associated with longer duration of hospitalization and mortality. Non-cardiac, but not cardiac, comorbidities were associated with significantly higher length of stay (beta coefficient 2.86 ± 0.27) and in-hospital mortality (OR 1.90, 95% confidence interval (CI) 1.60–2.23; p < 0.0001). Conclusions Cardiac and non-cardiac comorbidities differentially impact on in-hospital outcomes of older HF patients hospitalized in an Internal Medicine unit. Their more precise management will allow a reduction of avoidable hospitalization in HF patients. |
| format | Article |
| id | doaj-art-c26828e8b6ca4615beabb12a834a0f74 |
| institution | DOAJ |
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| language | English |
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| series | BMC Geriatrics |
| spelling | doaj-art-c26828e8b6ca4615beabb12a834a0f742025-08-20T03:08:44ZengBMCBMC Geriatrics1471-23182025-05-012511810.1186/s12877-025-06002-8Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patientsVeronica Murru0Elena Belfiori1Alessandro Sestu2Andrea Casanova3Carla Serra4Angelo Scuteri5Department of Medical Sciences and Public Health, University of CagliariDepartment of Medical Sciences and Public Health, University of CagliariDepartment of Medical Sciences and Public Health, University of CagliariDepartment of Medical Sciences and Public Health, University of CagliariInternal Medicine Unit – University Hospital Monserrato - Azienda Ospedaliero-Universitaria di Cagliari – CagliariDepartment of Medical Sciences and Public Health, University of CagliariAbstract Background Cardiac and non-cardiac comorbidities are highly prevalent in patients with heart failure (HF). The aim of the present study was to describe their selective impact on in-hospital outcomes (length of hospitalization and mortality) of HF patients hospitalized in an Internal Medicine Unit. Methods Between January 2017 and December 2022, 12,435 (6146 F, 6289 M) inpatients were hospitalized in our Internal Medicine Unit. HF was defined according to the International Statistical Classification of Diseases and Related Health Problems (ICD) version 9 codes 428, 402.01, 402.11, 402.91, 404.11, 404.13, 404.91, 404.93. Patients were classified by burden of overall, cardiac, and of non-cardiac comorbidities (0, 1, 2, 3 +). Multivariable regression models were used to assess associations between comorbidity burden and length of stay (linear regression) or in-hospital mortality (logistic regression). Results HF patients (1481, or 11.9% of all hospitalizations during the observation period) had on average comorbidity count of 1.6. An increasing number of comorbidities was associated with longer duration of hospitalization and mortality. Non-cardiac, but not cardiac, comorbidities were associated with significantly higher length of stay (beta coefficient 2.86 ± 0.27) and in-hospital mortality (OR 1.90, 95% confidence interval (CI) 1.60–2.23; p < 0.0001). Conclusions Cardiac and non-cardiac comorbidities differentially impact on in-hospital outcomes of older HF patients hospitalized in an Internal Medicine unit. Their more precise management will allow a reduction of avoidable hospitalization in HF patients.https://doi.org/10.1186/s12877-025-06002-8Heart failureHospitalizationComorbiditiesLength of stay |
| spellingShingle | Veronica Murru Elena Belfiori Alessandro Sestu Andrea Casanova Carla Serra Angelo Scuteri Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients BMC Geriatrics Heart failure Hospitalization Comorbidities Length of stay |
| title | Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients |
| title_full | Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients |
| title_fullStr | Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients |
| title_full_unstemmed | Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients |
| title_short | Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients |
| title_sort | patterns of comorbidities differentially impact on in hospital outcomes in heart failure patients |
| topic | Heart failure Hospitalization Comorbidities Length of stay |
| url | https://doi.org/10.1186/s12877-025-06002-8 |
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