The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities
ABSTRACT Objective To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies. Methods A total of 129 migraine patients wer...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70056 |
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| author | Zhi‐Ming Zhao Mei‐Mei Yang Xian‐Shu Zhao Fu‐Jun Wan Bao‐Li Ning Li‐Ming Zhang Jun Fu |
| author_facet | Zhi‐Ming Zhao Mei‐Mei Yang Xian‐Shu Zhao Fu‐Jun Wan Bao‐Li Ning Li‐Ming Zhang Jun Fu |
| author_sort | Zhi‐Ming Zhao |
| collection | DOAJ |
| description | ABSTRACT Objective To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies. Methods A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep. Serum specific IgG antibodies against 14 kinds of food were detected using enzyme‐linked immunosorbent assays. Results Patients with migraine diagnosis who had positive food specific IgG antibodies had significantly worse headaches, gastrointestinal and anxiety symptoms, compared to the patients with negative IgG antibodies. Patients with more IgG positive foods and higher total positive IgG concentration generally had worse migraine conditions, anxiety, depression, and gastrointestinal symptoms. Conclusion The effect of food specific IgG antibodies on severity of migraine and its comorbidities were antibody‐quantity and IgG‐concentration dependent. Future studies are warranted to explore the mechanism underlying such relationship. |
| format | Article |
| id | doaj-art-c263d6a67e4646119c829ee9f7323cde |
| institution | DOAJ |
| issn | 2050-4527 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-c263d6a67e4646119c829ee9f7323cde2025-08-20T02:41:43ZengWileyImmunity, Inflammation and Disease2050-45272024-11-011211n/an/a10.1002/iid3.70056The Impact of Food Specific IgG Antibodies on Migraine and Its ComorbiditiesZhi‐Ming Zhao0Mei‐Mei Yang1Xian‐Shu Zhao2Fu‐Jun Wan3Bao‐Li Ning4Li‐Ming Zhang5Jun Fu6Health Center of Screening and Prevention of Diseases First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaDepartment of Neurology Fourth Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaDepartment of Gastroenterology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaHealth Center of Screening and Prevention of Diseases First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaHealth Center of Screening and Prevention of Diseases First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaDepartment of Neurology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaHealth Center of Screening and Prevention of Diseases First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaABSTRACT Objective To investigate the differences in headache and comorbidity symptoms between migraine patients with negative and positive food specific IgG antibodies, and explore the correlation between these symptoms with food specific IgG antibodies. Methods A total of 129 migraine patients were enrolled. Seven questionnaires were used to gather information regarding the symptoms of migraine, gastrointestinal, depression, anxiety, and sleep. Serum specific IgG antibodies against 14 kinds of food were detected using enzyme‐linked immunosorbent assays. Results Patients with migraine diagnosis who had positive food specific IgG antibodies had significantly worse headaches, gastrointestinal and anxiety symptoms, compared to the patients with negative IgG antibodies. Patients with more IgG positive foods and higher total positive IgG concentration generally had worse migraine conditions, anxiety, depression, and gastrointestinal symptoms. Conclusion The effect of food specific IgG antibodies on severity of migraine and its comorbidities were antibody‐quantity and IgG‐concentration dependent. Future studies are warranted to explore the mechanism underlying such relationship.https://doi.org/10.1002/iid3.70056anxietydepressionfood specific IgG antibodiesgastrointestinal symptomsmigrainesleep disorders |
| spellingShingle | Zhi‐Ming Zhao Mei‐Mei Yang Xian‐Shu Zhao Fu‐Jun Wan Bao‐Li Ning Li‐Ming Zhang Jun Fu The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities Immunity, Inflammation and Disease anxiety depression food specific IgG antibodies gastrointestinal symptoms migraine sleep disorders |
| title | The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities |
| title_full | The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities |
| title_fullStr | The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities |
| title_full_unstemmed | The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities |
| title_short | The Impact of Food Specific IgG Antibodies on Migraine and Its Comorbidities |
| title_sort | impact of food specific igg antibodies on migraine and its comorbidities |
| topic | anxiety depression food specific IgG antibodies gastrointestinal symptoms migraine sleep disorders |
| url | https://doi.org/10.1002/iid3.70056 |
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