Immunohistochemical expression of PD1, LAG3, and CTLA4 in diffuse large B cell lymphoma, clinicopathological correlation, and prognostic value

Immunohistochemical expression of PD1, LAG3, and CTLA4 in diffuse large B cell lymphoma, clinicopathological correlation, and prognostic value

Abstract Background The tumor microenvironment has an important role in the growth and progression of diffuse large B-cell lymphoma (DLBCL). Immune checkpoint molecules, including PD1, LAG3, and CTLA4, are crucial to regulate the T cells function in the tumor microenvironment. Exploring the expressi...

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Bibliographic Details
Main Authors: Madonna I. William, Dina A Tantawy, Alyaa R. Elsergany, Amira K El-Hawary, Shaimaa M Yussif
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Journal of the Egyptian National Cancer Institute
Subjects:
DLBCL
Survival
PD1
CTLA4
LAG3
Online Access:https://doi.org/10.1186/s43046-025-00303-0
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