Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

Meiotic crossovers are produced when programmed double-strand breaks (DSBs) are repaired by recombination from homologous chromosomes (homologues). In a wide variety of organisms, meiotic HORMA-domain proteins are required to direct DSB repair towards homologues. This inter-homologue bias is require...

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Main Authors: Lukasz Wojtasz, Katrin Daniel, Ignasi Roig, Ewelina Bolcun-Filas, Huiling Xu, Verawan Boonsanay, Christian R Eckmann, Howard J Cooke, Maria Jasin, Scott Keeney, Michael J McKay, Attila Toth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000702&type=printable
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