Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila
Summary: An animal’s metabolic state strongly influences its behavior. Hungry animals prioritize food-seeking and feeding behaviors, while sated animals suppress these behaviors to engage in other activities. Additionally, neuronal activity and synaptic transmission are among the most energy-expensi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725005364 |
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| author | Jean-François De Backer Thomas Karges Julia Papst Zeynep Nigar Pınar Cristina Coman Robert Ahrends Yanjun Xu Cristina García-Cáceres Ilona C. Grunwald Kadow |
| author_facet | Jean-François De Backer Thomas Karges Julia Papst Zeynep Nigar Pınar Cristina Coman Robert Ahrends Yanjun Xu Cristina García-Cáceres Ilona C. Grunwald Kadow |
| author_sort | Jean-François De Backer |
| collection | DOAJ |
| description | Summary: An animal’s metabolic state strongly influences its behavior. Hungry animals prioritize food-seeking and feeding behaviors, while sated animals suppress these behaviors to engage in other activities. Additionally, neuronal activity and synaptic transmission are among the most energy-expensive processes. However, neurons do not uptake nutrients from the circulation. Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. However, how different glia subtypes sense metabolic state and modulate behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation of metabolic-state-dependent behavior. In food-deprived flies, astrocyte-like and perineurial glia promote foraging and feeding, respectively, while cortex glia suppress these behaviors. We further show that adenosine and adenosine receptors modulate intracellular calcium levels in these glia subtypes, which ultimately controls behavior. This study reveals a mechanism of how different glia subtypes sense an animal’s metabolic state and modulate its behavior accordingly. |
| format | Article |
| id | doaj-art-c26027bd0eb346fcaa4c44f8b73d0659 |
| institution | DOAJ |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-c26027bd0eb346fcaa4c44f8b73d06592025-08-20T03:21:51ZengElsevierCell Reports2211-12472025-06-0144611576510.1016/j.celrep.2025.115765Adenosine signaling in glia modulates metabolic state-dependent behavior in DrosophilaJean-François De Backer0Thomas Karges1Julia Papst2Zeynep Nigar Pınar3Cristina Coman4Robert Ahrends5Yanjun Xu6Cristina García-Cáceres7Ilona C. Grunwald Kadow8Institute of Physiology II, Faculty of Medicine, University of Bonn, Bonn, GermanyInstitute of Physiology II, Faculty of Medicine, University of Bonn, Bonn, GermanyInstitute of Physiology II, Faculty of Medicine, University of Bonn, Bonn, GermanyInstitute of Physiology II, Faculty of Medicine, University of Bonn, Bonn, GermanyInstitute of Analytical Chemistry, University of Vienna, Vienna, AustriaInstitute of Analytical Chemistry, University of Vienna, Vienna, AustriaInstitute of Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, GermanyInstitute of Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, GermanyInstitute of Physiology II, Faculty of Medicine, University of Bonn, Bonn, Germany; Corresponding authorSummary: An animal’s metabolic state strongly influences its behavior. Hungry animals prioritize food-seeking and feeding behaviors, while sated animals suppress these behaviors to engage in other activities. Additionally, neuronal activity and synaptic transmission are among the most energy-expensive processes. However, neurons do not uptake nutrients from the circulation. Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. However, how different glia subtypes sense metabolic state and modulate behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation of metabolic-state-dependent behavior. In food-deprived flies, astrocyte-like and perineurial glia promote foraging and feeding, respectively, while cortex glia suppress these behaviors. We further show that adenosine and adenosine receptors modulate intracellular calcium levels in these glia subtypes, which ultimately controls behavior. This study reveals a mechanism of how different glia subtypes sense an animal’s metabolic state and modulate its behavior accordingly.http://www.sciencedirect.com/science/article/pii/S2211124725005364CP: Metabolism |
| spellingShingle | Jean-François De Backer Thomas Karges Julia Papst Zeynep Nigar Pınar Cristina Coman Robert Ahrends Yanjun Xu Cristina García-Cáceres Ilona C. Grunwald Kadow Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila Cell Reports CP: Metabolism |
| title | Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila |
| title_full | Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila |
| title_fullStr | Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila |
| title_full_unstemmed | Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila |
| title_short | Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila |
| title_sort | adenosine signaling in glia modulates metabolic state dependent behavior in drosophila |
| topic | CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725005364 |
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