Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Background: Reduced short-chain fatty acids (SCFAs) in inflammatory bowel disease (IBD) impair the gut barrier and immune function, promoting inflammation and highlighting microbiome-targeted therapies’ therapeutic potential. The purpose of this meta-analysis was to study the changes in SCFAs in IBD...
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2025-07-01
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| author | Laura Chulenbayeva Zharkyn Jarmukhanov Karlygash Kaliyekova Samat Kozhakhmetov Almagul Kushugulova |
| author_facet | Laura Chulenbayeva Zharkyn Jarmukhanov Karlygash Kaliyekova Samat Kozhakhmetov Almagul Kushugulova |
| author_sort | Laura Chulenbayeva |
| collection | DOAJ |
| description | Background: Reduced short-chain fatty acids (SCFAs) in inflammatory bowel disease (IBD) impair the gut barrier and immune function, promoting inflammation and highlighting microbiome-targeted therapies’ therapeutic potential. The purpose of this meta-analysis was to study the changes in SCFAs in IBD and their potential role in the occurrence and development of IBD. Methods: The analysis employed a random-effects model to assess the standardized mean difference (SMD) with a 95% confidence interval. A literature search was conducted in databases from 2014 to 20 July 2024 to identify studies investigating SCFAs in IBD. Results: Subgroup analyses revealed a significant reduction in fecal SCFA levels—specifically butyrate, acetate, and propionate—in all IBD subgroups compared to healthy controls. Active IBD showed a greater decrease in butyrate (<i>p</i> = 0.004), and UC showed a notable reduction in propionate (<i>p</i> = 0.03). When comparing UC and CD, differences were observed mainly in propionate (SMD = −0.76, <i>p</i> = 0.00001). Dietary interventions in IBD patients led to increased SCFA levels, with butyrate showing the most improvement (SMD = 1.03), suggesting the potential therapeutic value of dietary modulation. Conclusions: In conclusion, this meta-analysis demonstrates a significant reduction in fecal SCFA levels in patients with IBD, particularly during active phases of the disease and most markedly in CD. |
| format | Article |
| id | doaj-art-c25cbb8c840844bdbcb5f315abb67469 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj-art-c25cbb8c840844bdbcb5f315abb674692025-08-20T02:45:37ZengMDPI AGBiomolecules2218-273X2025-07-01157101710.3390/biom15071017Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-AnalysisLaura Chulenbayeva0Zharkyn Jarmukhanov1Karlygash Kaliyekova2Samat Kozhakhmetov3Almagul Kushugulova4Laboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Astana 010000, KazakhstanLaboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Astana 010000, KazakhstanDepartment of Pharmacology, Medical University Astana, Astana 010000, KazakhstanLaboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Astana 010000, KazakhstanLaboratory of Microbiome, National Laboratory Astana, Nazarbayev University, Astana 010000, KazakhstanBackground: Reduced short-chain fatty acids (SCFAs) in inflammatory bowel disease (IBD) impair the gut barrier and immune function, promoting inflammation and highlighting microbiome-targeted therapies’ therapeutic potential. The purpose of this meta-analysis was to study the changes in SCFAs in IBD and their potential role in the occurrence and development of IBD. Methods: The analysis employed a random-effects model to assess the standardized mean difference (SMD) with a 95% confidence interval. A literature search was conducted in databases from 2014 to 20 July 2024 to identify studies investigating SCFAs in IBD. Results: Subgroup analyses revealed a significant reduction in fecal SCFA levels—specifically butyrate, acetate, and propionate—in all IBD subgroups compared to healthy controls. Active IBD showed a greater decrease in butyrate (<i>p</i> = 0.004), and UC showed a notable reduction in propionate (<i>p</i> = 0.03). When comparing UC and CD, differences were observed mainly in propionate (SMD = −0.76, <i>p</i> = 0.00001). Dietary interventions in IBD patients led to increased SCFA levels, with butyrate showing the most improvement (SMD = 1.03), suggesting the potential therapeutic value of dietary modulation. Conclusions: In conclusion, this meta-analysis demonstrates a significant reduction in fecal SCFA levels in patients with IBD, particularly during active phases of the disease and most markedly in CD.https://www.mdpi.com/2218-273X/15/7/1017short-chain fatty acidbutyrateacetatepropionateinflammatory bowel diseaseCrohn’s disease |
| spellingShingle | Laura Chulenbayeva Zharkyn Jarmukhanov Karlygash Kaliyekova Samat Kozhakhmetov Almagul Kushugulova Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis Biomolecules short-chain fatty acid butyrate acetate propionate inflammatory bowel disease Crohn’s disease |
| title | Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_full | Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_short | Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis |
| title_sort | quantitative alterations in short chain fatty acids in inflammatory bowel disease a systematic review and meta analysis |
| topic | short-chain fatty acid butyrate acetate propionate inflammatory bowel disease Crohn’s disease |
| url | https://www.mdpi.com/2218-273X/15/7/1017 |
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