Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis
Abstract Background Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered...
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BMC
2024-12-01
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| Series: | Journal of Inflammation |
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| Online Access: | https://doi.org/10.1186/s12950-024-00421-x |
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| author | Tannaz Jamialahmadi Željko Reiner Luis E. Simental-Mendia Wael Almahmeed Sercan Karav Ali H. Eid Francesco Giammarile Amirhossein Sahebkar |
| author_facet | Tannaz Jamialahmadi Željko Reiner Luis E. Simental-Mendia Wael Almahmeed Sercan Karav Ali H. Eid Francesco Giammarile Amirhossein Sahebkar |
| author_sort | Tannaz Jamialahmadi |
| collection | DOAJ |
| description | Abstract Background Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation. Therefore, in this meta-analysis the role of statins on inflammatory process in the artery wall was evaluated using this method since its actual validity for this purpose is not yet well established. Methods PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests evaluated publication bias in the meta-analysis. In cases where funnel plot asymmetry was observed, the “trim and fill” method was used to check the input of potentially missing studies. Results Findings of 10 clinical trials involving 373 subjects showed a remarkable reduction of arterial wall 18 F-FDG uptake according to target-to-background ratio (TBR) index after treatment with statins. Subgroup analysis showed a significant decrease in TBR with high-intensity and non-significant reduction of TBR with low-to-moderate-intensity statin therapy. Conclusion Treatment with statins suppressed arterial wall inflammation as shown by using 18 F-FDG PET-CT. |
| format | Article |
| id | doaj-art-c25bc09ca46545e79babaf97c384f16b |
| institution | DOAJ |
| issn | 1476-9255 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj-art-c25bc09ca46545e79babaf97c384f16b2025-08-20T02:39:51ZengBMCJournal of Inflammation1476-92552024-12-0121111010.1186/s12950-024-00421-xEffect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysisTannaz Jamialahmadi0Željko Reiner1Luis E. Simental-Mendia2Wael Almahmeed3Sercan Karav4Ali H. Eid5Francesco Giammarile6Amirhossein Sahebkar7Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical SciencesDepartment of Internal Medicine, University Hospital Center ZagrebBiomedical Research Unit, Instituto Mexicano Del Seguro SocialHeart and Vascular Institute, Cleveland Clinic Abu DhabiDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart UniversityDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar UniversityNuclear Medicine and Diagnostic Imaging Section, International Atomic Energy AgencyCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospitals, Saveetha UniversityAbstract Background Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation. Therefore, in this meta-analysis the role of statins on inflammatory process in the artery wall was evaluated using this method since its actual validity for this purpose is not yet well established. Methods PubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests evaluated publication bias in the meta-analysis. In cases where funnel plot asymmetry was observed, the “trim and fill” method was used to check the input of potentially missing studies. Results Findings of 10 clinical trials involving 373 subjects showed a remarkable reduction of arterial wall 18 F-FDG uptake according to target-to-background ratio (TBR) index after treatment with statins. Subgroup analysis showed a significant decrease in TBR with high-intensity and non-significant reduction of TBR with low-to-moderate-intensity statin therapy. Conclusion Treatment with statins suppressed arterial wall inflammation as shown by using 18 F-FDG PET-CT.https://doi.org/10.1186/s12950-024-00421-xStatinsAtherosclerosisInflammation18F-FDG PET-CTCardiovascular disease |
| spellingShingle | Tannaz Jamialahmadi Željko Reiner Luis E. Simental-Mendia Wael Almahmeed Sercan Karav Ali H. Eid Francesco Giammarile Amirhossein Sahebkar Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis Journal of Inflammation Statins Atherosclerosis Inflammation 18F-FDG PET-CT Cardiovascular disease |
| title | Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis |
| title_full | Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis |
| title_fullStr | Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis |
| title_full_unstemmed | Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis |
| title_short | Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis |
| title_sort | effect of statins on arterial wall inflammation as assessed by 18f fdg pet ct an updated systematic review and meta analysis |
| topic | Statins Atherosclerosis Inflammation 18F-FDG PET-CT Cardiovascular disease |
| url | https://doi.org/10.1186/s12950-024-00421-x |
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