Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation
In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb. The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight. The animals...
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Tsinghua University Press
2017-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016301240 |
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| author | Ilham Touiss Saloua Khatib Oussama Bekkouch Souliman Amrani Hicham Harnafi |
| author_facet | Ilham Touiss Saloua Khatib Oussama Bekkouch Souliman Amrani Hicham Harnafi |
| author_sort | Ilham Touiss |
| collection | DOAJ |
| description | In this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb. The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight. The animals were grouped as follows: normolipidemic control group (n = 8), hyperlipidemic control group (n = 8) and phenolic extract-treated group (n = 8) at a dose of 200 mg/kg body weight. After 7 h and 24 h treatment, the oral administration of the phenolic extract exerts a significant reduction of plasma total cholesterol, triglycerides and LDL-cholesterol concentrations (P < 0.001). On the other hand, we demonstrated that the phenolic extract prevents plasma lipid oxidation by 16% (P < 0.001), 20% (P < 0.001), 32% (P < 0.001) and 44% (P < 0.001) at a doses of 10, 25, 50 and 100 μg/mL, respectively. The results were compared with ascorbic acid used as standard synthetic antioxidant. HPLC analysis shows that the extract contains 4 major phenolics and is especially rich in rosmarinic acid. This finding indicates that the phenolic extract might be beneficial in lowering hyperlipidemia and preventing atherosclerosis. |
| format | Article |
| id | doaj-art-c259f5f3c2a04861a4f2fb475b4a98f0 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-c259f5f3c2a04861a4f2fb475b4a98f02025-02-03T06:34:55ZengTsinghua University PressFood Science and Human Wellness2213-45302017-03-0161283310.1016/j.fshw.2017.02.002Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidationIlham TouissSaloua KhatibOussama BekkouchSouliman AmraniHicham HarnafiIn this study we investigated the hypolipidemic and anti-lipoprotein-oxidation activities of phenolic extract from sweet basil a popular culinary herb. The hypolipidemic activity was studied in mice model injected intraperitoneally with Triton WR-1339 at a dose of 200 mg/kg body weight. The animals were grouped as follows: normolipidemic control group (n = 8), hyperlipidemic control group (n = 8) and phenolic extract-treated group (n = 8) at a dose of 200 mg/kg body weight. After 7 h and 24 h treatment, the oral administration of the phenolic extract exerts a significant reduction of plasma total cholesterol, triglycerides and LDL-cholesterol concentrations (P < 0.001). On the other hand, we demonstrated that the phenolic extract prevents plasma lipid oxidation by 16% (P < 0.001), 20% (P < 0.001), 32% (P < 0.001) and 44% (P < 0.001) at a doses of 10, 25, 50 and 100 μg/mL, respectively. The results were compared with ascorbic acid used as standard synthetic antioxidant. HPLC analysis shows that the extract contains 4 major phenolics and is especially rich in rosmarinic acid. This finding indicates that the phenolic extract might be beneficial in lowering hyperlipidemia and preventing atherosclerosis.http://www.sciencedirect.com/science/article/pii/S2213453016301240Sweet basilPhenolic acidsHypocholesterolaemiaHypotriglyceridaemiaLipoprotein-rich plasma oxidation |
| spellingShingle | Ilham Touiss Saloua Khatib Oussama Bekkouch Souliman Amrani Hicham Harnafi Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation Food Science and Human Wellness Sweet basil Phenolic acids Hypocholesterolaemia Hypotriglyceridaemia Lipoprotein-rich plasma oxidation |
| title | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation |
| title_full | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation |
| title_fullStr | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation |
| title_full_unstemmed | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation |
| title_short | Phenolic extract from Ocimum basilicum restores lipid metabolism in Triton WR-1339-induced hyperlipidemic mice and prevents lipoprotein-rich plasma oxidation |
| title_sort | phenolic extract from ocimum basilicum restores lipid metabolism in triton wr 1339 induced hyperlipidemic mice and prevents lipoprotein rich plasma oxidation |
| topic | Sweet basil Phenolic acids Hypocholesterolaemia Hypotriglyceridaemia Lipoprotein-rich plasma oxidation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016301240 |
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