Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive
Male breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass. An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1374032/full |
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| author | Xintong Xie Xiangyi Kong Xiangyi Kong Hongnan Jiang Jidong Gao Jidong Gao |
| author_facet | Xintong Xie Xiangyi Kong Xiangyi Kong Hongnan Jiang Jidong Gao Jidong Gao |
| author_sort | Xintong Xie |
| collection | DOAJ |
| description | Male breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass. An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifiable primary breast tumor. We report an intriguing case of a septuagenarian patient diagnosed with male occult breast cancer. The patient presented with both axillary lymph node enlargement and an associated axillary skin ulcer, and was subsequently diagnosed with male occult breast cancer with metastases to the axillary and clavicular lymph nodes, as well as more distant sites. His treatment involved a multidisciplinary approach, including HER2-targeted therapy, chemotherapy, axillary lymph node dissection, and radiotherapy. Regular follow-ups have shown that his condition remains stable. Notably, this is the first documented case of male occult breast cancer with distant metastasis that was successfully treated with surgery and radiotherapy following systemic therapy. This case highlights the complex clinical presentation and management of male occult breast cancer. Our findings suggest that surgical intervention may be a feasible option post-downstaging by systemic therapy, even in the presence of distant metastases. |
| format | Article |
| id | doaj-art-c249c4820102465fa0d5a2a8072fc937 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c249c4820102465fa0d5a2a8072fc9372025-02-11T10:59:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.13740321374032Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature diveXintong Xie0Xiangyi Kong1Xiangyi Kong2Hongnan Jiang3Jidong Gao4Jidong Gao5Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaMale breast cancer is a rare neoplasm, accounting for approximately 1% of all breast cancer cases. It typically presents as a painless, retroareolar mass. An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifiable primary breast tumor. We report an intriguing case of a septuagenarian patient diagnosed with male occult breast cancer. The patient presented with both axillary lymph node enlargement and an associated axillary skin ulcer, and was subsequently diagnosed with male occult breast cancer with metastases to the axillary and clavicular lymph nodes, as well as more distant sites. His treatment involved a multidisciplinary approach, including HER2-targeted therapy, chemotherapy, axillary lymph node dissection, and radiotherapy. Regular follow-ups have shown that his condition remains stable. Notably, this is the first documented case of male occult breast cancer with distant metastasis that was successfully treated with surgery and radiotherapy following systemic therapy. This case highlights the complex clinical presentation and management of male occult breast cancer. Our findings suggest that surgical intervention may be a feasible option post-downstaging by systemic therapy, even in the presence of distant metastases.https://www.frontiersin.org/articles/10.3389/fonc.2025.1374032/fullmale breast canceroccult breast cancersystemic therapyanti-HER2 targeted therapysurgery treatment |
| spellingShingle | Xintong Xie Xiangyi Kong Xiangyi Kong Hongnan Jiang Jidong Gao Jidong Gao Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive Frontiers in Oncology male breast cancer occult breast cancer systemic therapy anti-HER2 targeted therapy surgery treatment |
| title | Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| title_full | Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| title_fullStr | Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| title_full_unstemmed | Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| title_short | Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| title_sort | case report unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive |
| topic | male breast cancer occult breast cancer systemic therapy anti-HER2 targeted therapy surgery treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1374032/full |
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