Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/362189 |
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| author | Bryan D. James Brian Caffo Walter F. Stewart David Yousem Christos Davatzikos Brian S. Schwartz |
| author_facet | Bryan D. James Brian Caffo Walter F. Stewart David Yousem Christos Davatzikos Brian S. Schwartz |
| author_sort | Bryan D. James |
| collection | DOAJ |
| description | This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted. APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline. The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure. |
| format | Article |
| id | doaj-art-c240ae2687f248f1af568f2b35da66a2 |
| institution | DOAJ |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-c240ae2687f248f1af568f2b35da66a22025-08-20T03:23:16ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/362189362189Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead WorkersBryan D. James0Brian Caffo1Walter F. Stewart2David Yousem3Christos Davatzikos4Brian S. Schwartz5Rush University Alzheimer's Disease Center, Rush University Medical Center, Room 1038, Chicago, IL 60612, USADepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAThe Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21278, USADepartment of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USAThis study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted. APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline. The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure.http://dx.doi.org/10.4061/2011/362189 |
| spellingShingle | Bryan D. James Brian Caffo Walter F. Stewart David Yousem Christos Davatzikos Brian S. Schwartz Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers Journal of Aging Research |
| title | Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers |
| title_full | Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers |
| title_fullStr | Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers |
| title_full_unstemmed | Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers |
| title_short | Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers |
| title_sort | genetic risk factors for longitudinal changes in structural mri in former organolead workers |
| url | http://dx.doi.org/10.4061/2011/362189 |
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