The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients
Background: The management of multiple organ failure in the vulnerable cohort of cardiac surgery patients with cardiogenic shock remains a significant challenge, often impairing patient survival. A multimodal approach at targeting organ dysfunction seems to be a promising strategy, encompassing both...
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2025-06-01
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| author | Veronika Walter Ekaterina Hinrichs Tarek Alloush Aritz Perez Ruiz de Garibay Gregor Warnecke Wiebke Sommer Hanna Gravert Christina Grothusen Janine Becker Alexander Thiem Bernd Panholzer |
| author_facet | Veronika Walter Ekaterina Hinrichs Tarek Alloush Aritz Perez Ruiz de Garibay Gregor Warnecke Wiebke Sommer Hanna Gravert Christina Grothusen Janine Becker Alexander Thiem Bernd Panholzer |
| author_sort | Veronika Walter |
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| description | Background: The management of multiple organ failure in the vulnerable cohort of cardiac surgery patients with cardiogenic shock remains a significant challenge, often impairing patient survival. A multimodal approach at targeting organ dysfunction seems to be a promising strategy, encompassing both hemodynamic support as well as differentiated organ replacement therapy. Materials and Methods: In our retrospective study we examined the impact of the ADVOS (advanced organ support) system on overall outcomes and survival in an all-comers group of 22 cardiac surgery patients with postoperative cardiogenic shock and multiple organ failure. Aims: The objective of the study was to assess the feasibility and potential benefits of ADVOS treatment in this patient population. Results: The standard care management in combination with ADVOS therapy corrected acid–base balance (pH 7.33 vs. 7.44, <i>p</i> = 0.001; base excess −3.2 vs. 2.4 mmol/L, <i>p</i> < 0.001). This contributed to restoring hemodynamic balance after two consecutive ADVOS treatments (vasoactive inotropic score (VIS) 59 vs. 21, <i>p</i> = 0.007, noradrenaline 0.470 vs. 0.180 µg/kg/min, <i>p</i> = 0.009). Conclusions: Our findings indicate that ADVOS treatment is both feasible and safe, with a substantial proportion of patients demonstrating improvements in organ function and overall outcomes. |
| format | Article |
| id | doaj-art-c23bda00046c4c4fa5e49da5a9c1bd73 |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj-art-c23bda00046c4c4fa5e49da5a9c1bd732025-08-20T02:45:53ZengMDPI AGLife2075-17292025-06-01157104210.3390/life15071042The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery PatientsVeronika Walter0Ekaterina Hinrichs1Tarek Alloush2Aritz Perez Ruiz de Garibay3Gregor Warnecke4Wiebke Sommer5Hanna Gravert6Christina Grothusen7Janine Becker8Alexander Thiem9Bernd Panholzer10Department of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyADVITOS GmbH, 80992 Munich, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Cardiac Surgery, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyBackground: The management of multiple organ failure in the vulnerable cohort of cardiac surgery patients with cardiogenic shock remains a significant challenge, often impairing patient survival. A multimodal approach at targeting organ dysfunction seems to be a promising strategy, encompassing both hemodynamic support as well as differentiated organ replacement therapy. Materials and Methods: In our retrospective study we examined the impact of the ADVOS (advanced organ support) system on overall outcomes and survival in an all-comers group of 22 cardiac surgery patients with postoperative cardiogenic shock and multiple organ failure. Aims: The objective of the study was to assess the feasibility and potential benefits of ADVOS treatment in this patient population. Results: The standard care management in combination with ADVOS therapy corrected acid–base balance (pH 7.33 vs. 7.44, <i>p</i> = 0.001; base excess −3.2 vs. 2.4 mmol/L, <i>p</i> < 0.001). This contributed to restoring hemodynamic balance after two consecutive ADVOS treatments (vasoactive inotropic score (VIS) 59 vs. 21, <i>p</i> = 0.007, noradrenaline 0.470 vs. 0.180 µg/kg/min, <i>p</i> = 0.009). Conclusions: Our findings indicate that ADVOS treatment is both feasible and safe, with a substantial proportion of patients demonstrating improvements in organ function and overall outcomes.https://www.mdpi.com/2075-1729/15/7/1042cardiac surgeryliver failurecardiogenic shock |
| spellingShingle | Veronika Walter Ekaterina Hinrichs Tarek Alloush Aritz Perez Ruiz de Garibay Gregor Warnecke Wiebke Sommer Hanna Gravert Christina Grothusen Janine Becker Alexander Thiem Bernd Panholzer The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients Life cardiac surgery liver failure cardiogenic shock |
| title | The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients |
| title_full | The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients |
| title_fullStr | The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients |
| title_full_unstemmed | The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients |
| title_short | The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients |
| title_sort | advanced organ support advos hemodialysis system in postoperative cardiogenic shock and multiple organ failure first results in cardiac surgery patients |
| topic | cardiac surgery liver failure cardiogenic shock |
| url | https://www.mdpi.com/2075-1729/15/7/1042 |
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