AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo

Abstract The lack of regeneration in the human central nervous system (CNS) has major health implications. To address this, we previously used transgenic mouse models to show that neurogenesis can be stimulated in the adult mammalian retina by driving regeneration programs that other species activat...

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Main Authors: Marina Pavlou, Marlene Probst, Lew Kaplan, Elizaveta Filippova, Aric R Prieve, Fred Rieke, Thomas A Reh
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
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Online Access:https://doi.org/10.1038/s44321-025-00209-3
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