A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats
Diabetes mellitus (DM) is a highly prevalent public health problem characterized by hyperglycemia that causes complications due to the generation of reactive oxygen species and oxidative damage. Studies have shown that essential oils containing citral, such as lemongrass, have various biological act...
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Beilstein-Institut
2025-05-01
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| Series: | Beilstein Journal of Nanotechnology |
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| Online Access: | https://doi.org/10.3762/bjnano.16.48 |
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| author | Ailton Santos Sena-Júnior Cleverton Nascimento Santana Andrade Pedro Henrique Macedo Moura Jocsã Hémany Cândido dos Santos Cauãn Torres Trancoso Eloia Emanuelly Dias Silva Deise Maria Rego Rodrigues Silva Ênio Pereira Telles Luiz André Santos Silva Isabella Lima Dantas Teles Sara Fernanda Mota de Almeida Daniel Alves de Souza Jileno Ferreira Santos Felipe José Aidar Martins Ana Mara de Oliveira e Silva Sandra Lauton-Santos Guilherme Rodolfo Souza de Araujo Cristiane Bani Correa Rogéria De Souza Nunes Lysandro Pinto Borges Ana Amélia Moreira Lira |
| author_facet | Ailton Santos Sena-Júnior Cleverton Nascimento Santana Andrade Pedro Henrique Macedo Moura Jocsã Hémany Cândido dos Santos Cauãn Torres Trancoso Eloia Emanuelly Dias Silva Deise Maria Rego Rodrigues Silva Ênio Pereira Telles Luiz André Santos Silva Isabella Lima Dantas Teles Sara Fernanda Mota de Almeida Daniel Alves de Souza Jileno Ferreira Santos Felipe José Aidar Martins Ana Mara de Oliveira e Silva Sandra Lauton-Santos Guilherme Rodolfo Souza de Araujo Cristiane Bani Correa Rogéria De Souza Nunes Lysandro Pinto Borges Ana Amélia Moreira Lira |
| author_sort | Ailton Santos Sena-Júnior |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a highly prevalent public health problem characterized by hyperglycemia that causes complications due to the generation of reactive oxygen species and oxidative damage. Studies have shown that essential oils containing citral, such as lemongrass, have various biological activities, including bactericidal, antiviral, antifungal, antioxidant, and hypoglycemic effects. Therefore, this study aims to obtain a microemulsified formulation containing the essential oil of Cymbopogon flexuosus (EOCF) and to evaluate its antioxidant and antidiabetic activity in diabetic rats. The microemulsion (ME) was obtained after consulting the corresponding pseudoternary phase diagram and showed stability, isotropy, Newtonian behavior, nanometric size (15.2 nm), and pH 4.2. Both EOCF and the ME showed high antioxidant activity, but the ME resulted in greater antioxidant activity, potentiating the activity of isolated EOCF. Finally, male Wistar rats (3 months old, 200–250 g) with streptozotocin-induced type-1 DM were supplemented with EOCF and ME (32 mg/kg) for 21 days. Both EOCF and ME supplementation resulted in reduced blood glucose levels and improved lipid profiles when compared to the control group. Additionally, the ME was able to provide additional benefits, such as reduced liver damage, improved renal function, reduced systemic inflammation, and increased high-density lipoprotein levels. Overall, the results show that EOCF was efficiently incorporated into the microemulsion, improving its antioxidant activity and showing promising results for use in the treatment of DM via the oral route. |
| format | Article |
| id | doaj-art-c235d2d0053e4c0ebc03c0ce619c53d1 |
| institution | OA Journals |
| issn | 2190-4286 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj-art-c235d2d0053e4c0ebc03c0ce619c53d12025-08-20T01:56:53ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862025-05-0116161763610.3762/bjnano.16.482190-4286-16-48A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic ratsAilton Santos Sena-Júnior0Cleverton Nascimento Santana Andrade1Pedro Henrique Macedo Moura2Jocsã Hémany Cândido dos Santos3Cauãn Torres Trancoso4Eloia Emanuelly Dias Silva5Deise Maria Rego Rodrigues Silva6Ênio Pereira Telles7Luiz André Santos Silva8Isabella Lima Dantas Teles9Sara Fernanda Mota de Almeida10Daniel Alves de Souza11Jileno Ferreira Santos12Felipe José Aidar Martins13Ana Mara de Oliveira e Silva14Sandra Lauton-Santos15Guilherme Rodolfo Souza de Araujo16Cristiane Bani Correa17Rogéria De Souza Nunes18Lysandro Pinto Borges19Ana Amélia Moreira Lira20Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Biology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Morphology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Physical Education, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Nutrition, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Morphology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil Diabetes mellitus (DM) is a highly prevalent public health problem characterized by hyperglycemia that causes complications due to the generation of reactive oxygen species and oxidative damage. Studies have shown that essential oils containing citral, such as lemongrass, have various biological activities, including bactericidal, antiviral, antifungal, antioxidant, and hypoglycemic effects. Therefore, this study aims to obtain a microemulsified formulation containing the essential oil of Cymbopogon flexuosus (EOCF) and to evaluate its antioxidant and antidiabetic activity in diabetic rats. The microemulsion (ME) was obtained after consulting the corresponding pseudoternary phase diagram and showed stability, isotropy, Newtonian behavior, nanometric size (15.2 nm), and pH 4.2. Both EOCF and the ME showed high antioxidant activity, but the ME resulted in greater antioxidant activity, potentiating the activity of isolated EOCF. Finally, male Wistar rats (3 months old, 200–250 g) with streptozotocin-induced type-1 DM were supplemented with EOCF and ME (32 mg/kg) for 21 days. Both EOCF and ME supplementation resulted in reduced blood glucose levels and improved lipid profiles when compared to the control group. Additionally, the ME was able to provide additional benefits, such as reduced liver damage, improved renal function, reduced systemic inflammation, and increased high-density lipoprotein levels. Overall, the results show that EOCF was efficiently incorporated into the microemulsion, improving its antioxidant activity and showing promising results for use in the treatment of DM via the oral route.https://doi.org/10.3762/bjnano.16.48diabetes mellitusessential oillemongrassmicroemulsion |
| spellingShingle | Ailton Santos Sena-Júnior Cleverton Nascimento Santana Andrade Pedro Henrique Macedo Moura Jocsã Hémany Cândido dos Santos Cauãn Torres Trancoso Eloia Emanuelly Dias Silva Deise Maria Rego Rodrigues Silva Ênio Pereira Telles Luiz André Santos Silva Isabella Lima Dantas Teles Sara Fernanda Mota de Almeida Daniel Alves de Souza Jileno Ferreira Santos Felipe José Aidar Martins Ana Mara de Oliveira e Silva Sandra Lauton-Santos Guilherme Rodolfo Souza de Araujo Cristiane Bani Correa Rogéria De Souza Nunes Lysandro Pinto Borges Ana Amélia Moreira Lira A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats Beilstein Journal of Nanotechnology diabetes mellitus essential oil lemongrass microemulsion |
| title | A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats |
| title_full | A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats |
| title_fullStr | A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats |
| title_full_unstemmed | A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats |
| title_short | A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats |
| title_sort | formulation containing cymbopogon flexuosus essential oil improvement of biochemical parameters and oxidative stress in diabetic rats |
| topic | diabetes mellitus essential oil lemongrass microemulsion |
| url | https://doi.org/10.3762/bjnano.16.48 |
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