Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats
Interbody fusion devices are critical in spinal surgery to restore spinal stability, reduce pain and improve function. Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological in...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004985 |
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| author | Qiujiang Li Bowen Hu Linan Wang Lei Wang Cong Feng Zhuang Zhang Zhipeng Deng Yang Xiao Bo Yuan Xiangdong Zhu Xiangfeng Li Xi Yang Yueming Song Xingdong Zhang |
| author_facet | Qiujiang Li Bowen Hu Linan Wang Lei Wang Cong Feng Zhuang Zhang Zhipeng Deng Yang Xiao Bo Yuan Xiangdong Zhu Xiangfeng Li Xi Yang Yueming Song Xingdong Zhang |
| author_sort | Qiujiang Li |
| collection | DOAJ |
| description | Interbody fusion devices are critical in spinal surgery to restore spinal stability, reduce pain and improve function. Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological inertness limits bone regeneration and may lead to poor fusion. In this study, a novel strategy for preparing bioactive biomineralized PEEK cages was developed using a unique combination of osteoinductive CaP bioceramic fillings in the cage window, acid sulfonation and simulated body fluid incubation. In vitro experiments showed that biomineralized PEEK cages and CaP bioceramics regulate immunity and promote angiogenesis and bone integration via activation of hypoxia-inducible factor 1-alpha and cyclic guanosine monophosphate/protein kinase G signaling pathways. In vivo goat spinal fusion experiments demonstrated that PEEK cages filled with CaP bioceramics resulted in good bone growth and spinal fusion. Therefore, the high mechanical strength and good biocompatibility of biomineralized PEEK cages, together with the excellent bioactivity and degradation properties of CaP bioceramics, provide an ideal microenvironment for bone fusion. The development of this composite material not only addresses some of the limitations of existing fusion devices but also will facilitate the development of spinal fusion technology. |
| format | Article |
| id | doaj-art-c2346e05f56b412d889f4e99a7b589a9 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-c2346e05f56b412d889f4e99a7b589a92025-01-26T05:04:21ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145128147Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goatsQiujiang Li0Bowen Hu1Linan Wang2Lei Wang3Cong Feng4Zhuang Zhang5Zhipeng Deng6Yang Xiao7Bo Yuan8Xiangdong Zhu9Xiangfeng Li10Xi Yang11Yueming Song12Xingdong Zhang13Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaDepartment of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, China; Corresponding author.Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, China; Corresponding author.Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, 610064, Sichuan, ChinaNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, Sichuan, ChinaInterbody fusion devices are critical in spinal surgery to restore spinal stability, reduce pain and improve function. Polyetheretherketone (PEEK) has become a commonly used alternative material for fusion cages owing to its excellent mechanical properties and biocompatibility, but its biological inertness limits bone regeneration and may lead to poor fusion. In this study, a novel strategy for preparing bioactive biomineralized PEEK cages was developed using a unique combination of osteoinductive CaP bioceramic fillings in the cage window, acid sulfonation and simulated body fluid incubation. In vitro experiments showed that biomineralized PEEK cages and CaP bioceramics regulate immunity and promote angiogenesis and bone integration via activation of hypoxia-inducible factor 1-alpha and cyclic guanosine monophosphate/protein kinase G signaling pathways. In vivo goat spinal fusion experiments demonstrated that PEEK cages filled with CaP bioceramics resulted in good bone growth and spinal fusion. Therefore, the high mechanical strength and good biocompatibility of biomineralized PEEK cages, together with the excellent bioactivity and degradation properties of CaP bioceramics, provide an ideal microenvironment for bone fusion. The development of this composite material not only addresses some of the limitations of existing fusion devices but also will facilitate the development of spinal fusion technology.http://www.sciencedirect.com/science/article/pii/S2452199X24004985PolyetheretherketoneHydroxyapatiteBiomineralizationSpinal fusionGoat |
| spellingShingle | Qiujiang Li Bowen Hu Linan Wang Lei Wang Cong Feng Zhuang Zhang Zhipeng Deng Yang Xiao Bo Yuan Xiangdong Zhu Xiangfeng Li Xi Yang Yueming Song Xingdong Zhang Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats Bioactive Materials Polyetheretherketone Hydroxyapatite Biomineralization Spinal fusion Goat |
| title | Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats |
| title_full | Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats |
| title_fullStr | Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats |
| title_full_unstemmed | Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats |
| title_short | Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats |
| title_sort | biomineralized peek cages containing osteoinductive cap bioceramics promote spinal fusion in goats |
| topic | Polyetheretherketone Hydroxyapatite Biomineralization Spinal fusion Goat |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004985 |
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