The host response to influenza infections in human lung and macrophages cell lines
Abstract Objective The innate immune response of an infected host is an essential defense mechanism to fight influenza virus infections in the respiratory tract. This response is essential to limit virus replication and spread. However, an exacerbated response may cause severe immune-pathologies. Th...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Genomic Data |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12863-025-01341-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849235401535913984 |
|---|---|
| author | Carmen Aguilar Ruth Lydia Olga Lambertz Mark Heise Ana Eulalio Klaus Schughart |
| author_facet | Carmen Aguilar Ruth Lydia Olga Lambertz Mark Heise Ana Eulalio Klaus Schughart |
| author_sort | Carmen Aguilar |
| collection | DOAJ |
| description | Abstract Objective The innate immune response of an infected host is an essential defense mechanism to fight influenza virus infections in the respiratory tract. This response is essential to limit virus replication and spread. However, an exacerbated response may cause severe immune-pathologies. Therefore, it is very important to better understand innate immune responses at the level of its molecular networks in the context of viral infections. Data We infected human lung adenocarcinoma (A549) and human monocytic (THP-1) cells with H3N2 influenza virus A virus and performed transcriptome analysis using next generation RNA sequencing at various times post infection. We report raw sequence data and normalized log2 transformed gene expression values. This data will allow researchers in the field to identify differentially expressed genes and pathways between the two cell types and over times post infection. Furthermore, our data enables comparisons to molecular studies performed in humans and animal models in the context of respiratory viral infections. |
| format | Article |
| id | doaj-art-c22f3bec4f9540babe2e0a05fa1a6ebe |
| institution | Kabale University |
| issn | 2730-6844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomic Data |
| spelling | doaj-art-c22f3bec4f9540babe2e0a05fa1a6ebe2025-08-20T04:02:49ZengBMCBMC Genomic Data2730-68442025-07-012611510.1186/s12863-025-01341-2The host response to influenza infections in human lung and macrophages cell linesCarmen Aguilar0Ruth Lydia Olga Lambertz1Mark Heise2Ana Eulalio3Klaus Schughart4Institute of Molecular Infection Biology (IMIB), University of WürzburgCJD BraunschweigDepartment of Genetics, University of North Carolina at Chapel HillCenter for Neuroscience and Cell Biology (CNC-UC), Centre for Innovative Biomedicine and Biotechnology (CIBB), University of CoimbraInstitute of Virology Münster, University of MünsterAbstract Objective The innate immune response of an infected host is an essential defense mechanism to fight influenza virus infections in the respiratory tract. This response is essential to limit virus replication and spread. However, an exacerbated response may cause severe immune-pathologies. Therefore, it is very important to better understand innate immune responses at the level of its molecular networks in the context of viral infections. Data We infected human lung adenocarcinoma (A549) and human monocytic (THP-1) cells with H3N2 influenza virus A virus and performed transcriptome analysis using next generation RNA sequencing at various times post infection. We report raw sequence data and normalized log2 transformed gene expression values. This data will allow researchers in the field to identify differentially expressed genes and pathways between the two cell types and over times post infection. Furthermore, our data enables comparisons to molecular studies performed in humans and animal models in the context of respiratory viral infections.https://doi.org/10.1186/s12863-025-01341-2InfluenzaHumanLung cellsMacrophageTranscriptome |
| spellingShingle | Carmen Aguilar Ruth Lydia Olga Lambertz Mark Heise Ana Eulalio Klaus Schughart The host response to influenza infections in human lung and macrophages cell lines BMC Genomic Data Influenza Human Lung cells Macrophage Transcriptome |
| title | The host response to influenza infections in human lung and macrophages cell lines |
| title_full | The host response to influenza infections in human lung and macrophages cell lines |
| title_fullStr | The host response to influenza infections in human lung and macrophages cell lines |
| title_full_unstemmed | The host response to influenza infections in human lung and macrophages cell lines |
| title_short | The host response to influenza infections in human lung and macrophages cell lines |
| title_sort | host response to influenza infections in human lung and macrophages cell lines |
| topic | Influenza Human Lung cells Macrophage Transcriptome |
| url | https://doi.org/10.1186/s12863-025-01341-2 |
| work_keys_str_mv | AT carmenaguilar thehostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT ruthlydiaolgalambertz thehostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT markheise thehostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT anaeulalio thehostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT klausschughart thehostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT carmenaguilar hostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT ruthlydiaolgalambertz hostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT markheise hostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT anaeulalio hostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines AT klausschughart hostresponsetoinfluenzainfectionsinhumanlungandmacrophagescelllines |