Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties
Quantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate the conventional X-ray mammography, where the projection of displacement in...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2011/540820 |
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| _version_ | 1849684394979098624 |
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| author | Z. G. Wang Y. Liu G. Wang L. Z. Sun |
| author_facet | Z. G. Wang Y. Liu G. Wang L. Z. Sun |
| author_sort | Z. G. Wang |
| collection | DOAJ |
| description | Quantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate the conventional X-ray mammography, where the projection of displacement information is acquired instead of full three-dimensional (3D) vector. The elastic parameters of normal and cancerous breast tissues are identified by minimizing the difference between the measurement and the corresponding computational prediction. An adjoint method is derived to calculate the gradient of the objective function. Simulations are conducted on a 3D breast phantom consisting of the fatty tissue, glandular tissue, and cancerous tumor, whose mechanical responses are hyperelastic in nature. The material parameters are identified with consideration of measurement error. The results demonstrate that the projective displacements acquired in X-ray mammography provide sufficient constitutive information of the tumor and prove the usability and robustness of the proposed method and algorithm. |
| format | Article |
| id | doaj-art-c22ef89ef55d451da220a227e726c20a |
| institution | DOAJ |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-c22ef89ef55d451da220a227e726c20a2025-08-20T03:23:29ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/540820540820Nonlinear Elasto-Mammography for Characterization of Breast Tissue PropertiesZ. G. Wang0Y. Liu1G. Wang2L. Z. Sun3Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, USACooper Tire and Rubber Company, Findlay, OH 45840, USASchool of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA 24061, USADepartment of Civil and Environmental Engineering, University of California, Irvine, CA 92697-2175, USAQuantification of the mechanical behavior of normal and cancerous tissues has important implication in the diagnosis of breast tumor. The present work extends the authors' nonlinear elastography framework to incorporate the conventional X-ray mammography, where the projection of displacement information is acquired instead of full three-dimensional (3D) vector. The elastic parameters of normal and cancerous breast tissues are identified by minimizing the difference between the measurement and the corresponding computational prediction. An adjoint method is derived to calculate the gradient of the objective function. Simulations are conducted on a 3D breast phantom consisting of the fatty tissue, glandular tissue, and cancerous tumor, whose mechanical responses are hyperelastic in nature. The material parameters are identified with consideration of measurement error. The results demonstrate that the projective displacements acquired in X-ray mammography provide sufficient constitutive information of the tumor and prove the usability and robustness of the proposed method and algorithm.http://dx.doi.org/10.1155/2011/540820 |
| spellingShingle | Z. G. Wang Y. Liu G. Wang L. Z. Sun Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties International Journal of Biomedical Imaging |
| title | Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties |
| title_full | Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties |
| title_fullStr | Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties |
| title_full_unstemmed | Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties |
| title_short | Nonlinear Elasto-Mammography for Characterization of Breast Tissue Properties |
| title_sort | nonlinear elasto mammography for characterization of breast tissue properties |
| url | http://dx.doi.org/10.1155/2011/540820 |
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