Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children
Background. Washed microbiota transplantation (WMT) as the improved methods of fecal microbiota transplantation has been employed as a therapeutic approach for ameliorating symptoms associated with autism spectrum disorder (ASD). In this context, colonic transendoscopic enteral tubing (TET) has been...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/7838601 |
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| author | Qing-Fen Yuan Hui-Yi Wu Xian-Yun Chen Ya-Mei Zheng Song-Lin Fu Xing-He Wang Jian-Wei Zhu Jian-Dong Guo Xing-Xiang He Li-Hao Wu |
| author_facet | Qing-Fen Yuan Hui-Yi Wu Xian-Yun Chen Ya-Mei Zheng Song-Lin Fu Xing-He Wang Jian-Wei Zhu Jian-Dong Guo Xing-Xiang He Li-Hao Wu |
| author_sort | Qing-Fen Yuan |
| collection | DOAJ |
| description | Background. Washed microbiota transplantation (WMT) as the improved methods of fecal microbiota transplantation has been employed as a therapeutic approach for ameliorating symptoms associated with autism spectrum disorder (ASD). In this context, colonic transendoscopic enteral tubing (TET) has been utilized as a novel procedure for administering WMT. Methods. Data of children with ASD who received WMT by TET were retrospectively reviewed, including bowel preparation methods, TET operation time, success rate, tube retention time, the comfort of children, adverse events, and parent satisfaction. Results. A total of 38 participants underwent 124 colonic TET catheterization procedures. The average time of TET operation was 15 minutes, and the success rate was 100% (124/124). There was no significant difference in TET operation time between high-seniority physicians and low-seniority physicians. In 123 procedures (99%), the TET tube allowed the completion of WMT treatment for 6 consecutive days. In 118 procedures (95.2%), the tube was detached spontaneously after the end of the treatment course, and the average TET tube retention time was 8 days. There was no incidence of tube blockage during the treatment course. No severe adverse events occurred during follow-up. Parents of all participants reported a high level of satisfaction with TET. Conclusion. Colonic TET is a safe and feasible method for WMT in children with ASD. |
| format | Article |
| id | doaj-art-c22e93c21bc1490fac0386fffb80f6ba |
| institution | DOAJ |
| issn | 1687-630X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c22e93c21bc1490fac0386fffb80f6ba2025-08-20T03:23:29ZengWileyGastroenterology Research and Practice1687-630X2023-01-01202310.1155/2023/7838601Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic ChildrenQing-Fen Yuan0Hui-Yi Wu1Xian-Yun Chen2Ya-Mei Zheng3Song-Lin Fu4Xing-He Wang5Jian-Wei Zhu6Jian-Dong Guo7Xing-Xiang He8Li-Hao Wu9Department of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyInner Mongolia Ewenki Autonomous Banner People’s HospitalInner Mongolia Ewenki Autonomous Banner People’s HospitalInner Mongolia Ewenki Autonomous Banner People’s HospitalInner Mongolia Ewenki Autonomous Banner People’s HospitalDepartment of GastroenterologyDepartment of GastroenterologyBackground. Washed microbiota transplantation (WMT) as the improved methods of fecal microbiota transplantation has been employed as a therapeutic approach for ameliorating symptoms associated with autism spectrum disorder (ASD). In this context, colonic transendoscopic enteral tubing (TET) has been utilized as a novel procedure for administering WMT. Methods. Data of children with ASD who received WMT by TET were retrospectively reviewed, including bowel preparation methods, TET operation time, success rate, tube retention time, the comfort of children, adverse events, and parent satisfaction. Results. A total of 38 participants underwent 124 colonic TET catheterization procedures. The average time of TET operation was 15 minutes, and the success rate was 100% (124/124). There was no significant difference in TET operation time between high-seniority physicians and low-seniority physicians. In 123 procedures (99%), the TET tube allowed the completion of WMT treatment for 6 consecutive days. In 118 procedures (95.2%), the tube was detached spontaneously after the end of the treatment course, and the average TET tube retention time was 8 days. There was no incidence of tube blockage during the treatment course. No severe adverse events occurred during follow-up. Parents of all participants reported a high level of satisfaction with TET. Conclusion. Colonic TET is a safe and feasible method for WMT in children with ASD.http://dx.doi.org/10.1155/2023/7838601 |
| spellingShingle | Qing-Fen Yuan Hui-Yi Wu Xian-Yun Chen Ya-Mei Zheng Song-Lin Fu Xing-He Wang Jian-Wei Zhu Jian-Dong Guo Xing-Xiang He Li-Hao Wu Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children Gastroenterology Research and Practice |
| title | Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children |
| title_full | Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children |
| title_fullStr | Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children |
| title_full_unstemmed | Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children |
| title_short | Colonic Endoscopic Tubing Is Safe and Effective Approach for Washed Microbiota Transplantation in Autistic Children |
| title_sort | colonic endoscopic tubing is safe and effective approach for washed microbiota transplantation in autistic children |
| url | http://dx.doi.org/10.1155/2023/7838601 |
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