Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors
Introduction. Cardiovascular disease (CVD) is the common cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Causes of CVD in ESRD patients are multifactorial. Ventricular arrhythmia is known as the leading cause of sudden death in dialysis patients. QT disper...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2021-06-01
|
| Series: | Jurnal Penyakit Dalam Indonesia |
| Subjects: | |
| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/573/274 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239453559259136 |
|---|---|
| author | Arief Pattiiha orcid Muhammad Yamin Aida Lydia Murdani Abdullah |
| author_facet | Arief Pattiiha orcid Muhammad Yamin Aida Lydia Murdani Abdullah |
| author_sort | Arief Pattiiha orcid |
| collection | DOAJ |
| description | Introduction. Cardiovascular disease (CVD) is the common cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Causes of CVD in ESRD patients are multifactorial. Ventricular arrhythmia is known as the leading cause of sudden death in dialysis patients. QT dispersion, which is measured from electrocardiography (ECG), is known as one of the parameters to assess the risk of arrhythmia in HD patients. This study aimed to determine the proportion of pre-dialysis prolonged QT dispersion in chronic twice-weekly HD patients and the associated factors.
Methods. A cross-sectional study was conducted among HD patients age ≥18 years with dialysis duration of at least three months in Cipto Mangunkusumo Hospital during May–June 2019. Electrocardiography, echocardiography, and blood samples were taken before the dialysis session. Bivariate analysis using Chi-square and Fisher’s exact test was performed on each variable. Significant results were further analysed using logistic regression.
Results. A total of 142 subjects were included in this study. The mean age of subjects was 49 (standard deviation (SD) 15) years. Prolonged QT dispersion was found in 51 subjects (35.9%). Multivariate analysis showed prolonged QT dispersion was significantly correlated with systolic dysfunction (PR=1.875 (CI 95% 1.234-2.848); p=0.006) and left ventricle hypertrophy (PR=2.361 (CI 95% 1.032-5.403); p=0.019). Age, diabetes mellitus, hypokalemia, hypomagnesemia, and diastolic dysfunction were not significantly correlated with QT dispersion (p>0.05).
Conclusion. The proportion of pre-dialysis prolonged QT dispersion in twice-weekly chronic hemodialysis patients in RSCM is 35.9% and associated with systolic dysfunction and left ventricle hypertrophy. |
| format | Article |
| id | doaj-art-c22d69388dc64599adafc013dae51eaa |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2021-06-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-c22d69388dc64599adafc013dae51eaa2025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212021-06-01829398http://dx.doi.org/10.7454/jpdi.v8i2.573Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated FactorsArief Pattiiha orcid0Muhammad Yamin1Aida Lydia2Murdani Abdullah3Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia Indonesia Divisi Kardiologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Divisi Ginjal Hipertensi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Unit Epidemiologi Klinik, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN dr. Cipto Mangunkusumo, Jakarta Indonesia Introduction. Cardiovascular disease (CVD) is the common cause of mortality in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Causes of CVD in ESRD patients are multifactorial. Ventricular arrhythmia is known as the leading cause of sudden death in dialysis patients. QT dispersion, which is measured from electrocardiography (ECG), is known as one of the parameters to assess the risk of arrhythmia in HD patients. This study aimed to determine the proportion of pre-dialysis prolonged QT dispersion in chronic twice-weekly HD patients and the associated factors. Methods. A cross-sectional study was conducted among HD patients age ≥18 years with dialysis duration of at least three months in Cipto Mangunkusumo Hospital during May–June 2019. Electrocardiography, echocardiography, and blood samples were taken before the dialysis session. Bivariate analysis using Chi-square and Fisher’s exact test was performed on each variable. Significant results were further analysed using logistic regression. Results. A total of 142 subjects were included in this study. The mean age of subjects was 49 (standard deviation (SD) 15) years. Prolonged QT dispersion was found in 51 subjects (35.9%). Multivariate analysis showed prolonged QT dispersion was significantly correlated with systolic dysfunction (PR=1.875 (CI 95% 1.234-2.848); p=0.006) and left ventricle hypertrophy (PR=2.361 (CI 95% 1.032-5.403); p=0.019). Age, diabetes mellitus, hypokalemia, hypomagnesemia, and diastolic dysfunction were not significantly correlated with QT dispersion (p>0.05). Conclusion. The proportion of pre-dialysis prolonged QT dispersion in twice-weekly chronic hemodialysis patients in RSCM is 35.9% and associated with systolic dysfunction and left ventricle hypertrophy.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/573/274qt dispersionelectrocardiographyechocardiographyhemodialysis |
| spellingShingle | Arief Pattiiha orcid Muhammad Yamin Aida Lydia Murdani Abdullah Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors Jurnal Penyakit Dalam Indonesia qt dispersion electrocardiography echocardiography hemodialysis |
| title | Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors |
| title_full | Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors |
| title_fullStr | Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors |
| title_full_unstemmed | Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors |
| title_short | Proportion of Pre-dialysis Prolonged QT Dispersion in Twice-Weekly Chronic Hemodialysis Patients and Its Associated Factors |
| title_sort | proportion of pre dialysis prolonged qt dispersion in twice weekly chronic hemodialysis patients and its associated factors |
| topic | qt dispersion electrocardiography echocardiography hemodialysis |
| url | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/573/274 |
| work_keys_str_mv | AT ariefpattiihaorcid proportionofpredialysisprolongedqtdispersionintwiceweeklychronichemodialysispatientsanditsassociatedfactors AT muhammadyamin proportionofpredialysisprolongedqtdispersionintwiceweeklychronichemodialysispatientsanditsassociatedfactors AT aidalydia proportionofpredialysisprolongedqtdispersionintwiceweeklychronichemodialysispatientsanditsassociatedfactors AT murdaniabdullah proportionofpredialysisprolongedqtdispersionintwiceweeklychronichemodialysispatientsanditsassociatedfactors |