The effect of allergic rhinitis treatment on asthma control: a systematic review
Abstract Asthma and allergic rhinitis (AR) are common disorders of the respiratory tract that often coincide. Control of AR symptoms can improve asthma outcomes in patients with co-existing diseases. Our aim is to produce a systematic review of the effectiveness of conventional anti-AR medication fo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Primary Care Respiratory Medicine |
| Online Access: | https://doi.org/10.1038/s41533-024-00408-4 |
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| author | Ellen Tameeris Arthur M. Bohnen Patrick J. E. Bindels Gijs Elshout |
| author_facet | Ellen Tameeris Arthur M. Bohnen Patrick J. E. Bindels Gijs Elshout |
| author_sort | Ellen Tameeris |
| collection | DOAJ |
| description | Abstract Asthma and allergic rhinitis (AR) are common disorders of the respiratory tract that often coincide. Control of AR symptoms can improve asthma outcomes in patients with co-existing diseases. Our aim is to produce a systematic review of the effectiveness of conventional anti-AR medication for asthma outcomes in patients with both diseases. The Embase, Medline and Cochrane databases were searched for publications up to October 2024. Randomised controlled trials (RCTs) that reported objective (OAO) or subjective asthma outcomes (SAO) and compared the efficacy of anti-AR medication to placebo or conventional asthma medication were included. Included medication interventions were antihistamines (AH), corticosteroids and leukotriene receptor antagonists (LRA). We included thirty-three RCTs. Six had an exclusively paediatric study population, 17 a partially paediatric study population. No clinically relevant improvements were seen in SAO. Quality of life (QoL) showed a significant and clinically relevant improvement in five studies. A significant and clinically relevant improvement of OAO was seen in four studies. LRAs did not show significant improvements from baseline. When compared, corticosteroids performed significantly better than LRAs. Significant improvements in both OAO and SAO were seen more often in studies with AHs than with corticosteroids. Anti-allergic initiated AHs and corticosteroids seemed to have a positive effect on asthma outcomes, with AHs having the tendency to elicit more changes in outcomes than the other studied medication groups. LRAs do not seem to influence asthma outcomes. Most significant improvements were seen in QoL and OAO. SAO did not show clinically relevant improvements. |
| format | Article |
| id | doaj-art-c22d2ae3b459455e8edae9492c58c607 |
| institution | Kabale University |
| issn | 2055-1010 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Primary Care Respiratory Medicine |
| spelling | doaj-art-c22d2ae3b459455e8edae9492c58c6072025-01-19T12:10:47ZengNature Portfolionpj Primary Care Respiratory Medicine2055-10102025-01-0135111210.1038/s41533-024-00408-4The effect of allergic rhinitis treatment on asthma control: a systematic reviewEllen Tameeris0Arthur M. Bohnen1Patrick J. E. Bindels2Gijs Elshout3Erasmus MC, Department of General PracticeErasmus MC, Department of General PracticeErasmus MC, Department of General PracticeErasmus MC, Department of General PracticeAbstract Asthma and allergic rhinitis (AR) are common disorders of the respiratory tract that often coincide. Control of AR symptoms can improve asthma outcomes in patients with co-existing diseases. Our aim is to produce a systematic review of the effectiveness of conventional anti-AR medication for asthma outcomes in patients with both diseases. The Embase, Medline and Cochrane databases were searched for publications up to October 2024. Randomised controlled trials (RCTs) that reported objective (OAO) or subjective asthma outcomes (SAO) and compared the efficacy of anti-AR medication to placebo or conventional asthma medication were included. Included medication interventions were antihistamines (AH), corticosteroids and leukotriene receptor antagonists (LRA). We included thirty-three RCTs. Six had an exclusively paediatric study population, 17 a partially paediatric study population. No clinically relevant improvements were seen in SAO. Quality of life (QoL) showed a significant and clinically relevant improvement in five studies. A significant and clinically relevant improvement of OAO was seen in four studies. LRAs did not show significant improvements from baseline. When compared, corticosteroids performed significantly better than LRAs. Significant improvements in both OAO and SAO were seen more often in studies with AHs than with corticosteroids. Anti-allergic initiated AHs and corticosteroids seemed to have a positive effect on asthma outcomes, with AHs having the tendency to elicit more changes in outcomes than the other studied medication groups. LRAs do not seem to influence asthma outcomes. Most significant improvements were seen in QoL and OAO. SAO did not show clinically relevant improvements.https://doi.org/10.1038/s41533-024-00408-4 |
| spellingShingle | Ellen Tameeris Arthur M. Bohnen Patrick J. E. Bindels Gijs Elshout The effect of allergic rhinitis treatment on asthma control: a systematic review npj Primary Care Respiratory Medicine |
| title | The effect of allergic rhinitis treatment on asthma control: a systematic review |
| title_full | The effect of allergic rhinitis treatment on asthma control: a systematic review |
| title_fullStr | The effect of allergic rhinitis treatment on asthma control: a systematic review |
| title_full_unstemmed | The effect of allergic rhinitis treatment on asthma control: a systematic review |
| title_short | The effect of allergic rhinitis treatment on asthma control: a systematic review |
| title_sort | effect of allergic rhinitis treatment on asthma control a systematic review |
| url | https://doi.org/10.1038/s41533-024-00408-4 |
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