CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor

CCL5 Induces a Sarcopenic-like Phenotype via the CCR5 Receptor

Sarcopenia corresponds to a decrease in muscle mass and strength. CCL5 is a new myokine whose expression, along with the CCR5 receptor, is increased in sarcopenic muscle. Therefore, we evaluated whether CCL5 and CCR5 induce a sarcopenic-like effect on skeletal muscle tissue and cultured muscle cells...

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Main Authors: Francisco Aguirre, Franco Tacchi, Mayalen Valero-Breton, Josué Orozco-Aguilar, Sabrina Conejeros-Lillo, Josefa Bonicioli, Renata Iturriaga-Jofré, Daniel Cabrera, Jorge A. Soto, Mauricio Castro-Sepúlveda, Marianny Portal-Rodríguez, Álvaro A. Elorza, Andrea Matamoros, Felipe Simon, Claudio Cabello-Verrugio
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
Subjects:
sarcopenia
CCL5
CCR5
oxidative stress
ubiquitin–proteasome system
protein synthesis
Online Access:https://www.mdpi.com/2076-3921/14/1/84
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