In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases

Background: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells obtained from patients with DLD.

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Main Authors: Veronika Sekerova, Daniela Subrtova, Frantisek Mrazek, Agata Gibejova, Vitezslav Kolek, Roland M. du Bois, Martin Petrek
Format: Article
Language:English
Published: Wiley 2003-01-01
Series:Mediators of Inflammation
Subjects:
Online Access:http://dx.doi.org/10.1080/09629350310001599657
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author Veronika Sekerova
Daniela Subrtova
Frantisek Mrazek
Agata Gibejova
Vitezslav Kolek
Roland M. du Bois
Martin Petrek
author_facet Veronika Sekerova
Daniela Subrtova
Frantisek Mrazek
Agata Gibejova
Vitezslav Kolek
Roland M. du Bois
Martin Petrek
author_sort Veronika Sekerova
collection DOAJ
description Background: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells obtained from patients with DLD.
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publishDate 2003-01-01
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series Mediators of Inflammation
spelling doaj-art-c223805f1d224516a9f9f1ba5304fb2c2025-08-20T03:23:27ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112421522010.1080/09629350310001599657In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseasesVeronika Sekerova0Daniela Subrtova1Frantisek Mrazek2Agata Gibejova3Vitezslav Kolek4Roland M. du Bois5Martin Petrek6Department of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicDepartment of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicDepartment of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicDepartment of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicDepartment of Respiratory Medicine, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicInterstitial Lung Disease Unit, Royal Brompton Hospital, London, UKDepartment of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech RepublicBackground: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells obtained from patients with DLD.http://dx.doi.org/10.1080/09629350310001599657DexamethasoneCyclosporin APentoxifyllineSarcoidosisRANTESGlucocorticoidsBronchoalveolar cells.
spellingShingle Veronika Sekerova
Daniela Subrtova
Frantisek Mrazek
Agata Gibejova
Vitezslav Kolek
Roland M. du Bois
Martin Petrek
In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
Mediators of Inflammation
Dexamethasone
Cyclosporin A
Pentoxifylline
Sarcoidosis
RANTES
Glucocorticoids
Bronchoalveolar cells.
title In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
title_full In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
title_fullStr In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
title_full_unstemmed In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
title_short In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
title_sort in vitro pharmacoregulation of cc chemokine ligand 5 and its receptor ccr5 in diffuse lung diseases
topic Dexamethasone
Cyclosporin A
Pentoxifylline
Sarcoidosis
RANTES
Glucocorticoids
Bronchoalveolar cells.
url http://dx.doi.org/10.1080/09629350310001599657
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