INHIBITORS OF ANGIOGENESIS IN BRAIN TUMORS – REVIEW
Malignant glial and metastatic tumors are highly vascularized tumors and like all solid tumors, they require angiogenesis for their growth. [1] For glioblastoma (GBM) this microvascularization is very likely and those vessels have abnormal structure, shape and organization.[2] The permeability of...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Union of Scientists - Stara Zagora
2019-02-01
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| Series: | Science & Research |
| Online Access: |
http://www.sandtr.org/download.php?id=33
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| Summary: | Malignant glial and metastatic tumors are highly vascularized tumors and like all solid tumors, they require angiogenesis for their growth. [1] For glioblastoma (GBM) this microvascularization is very likely and those vessels have abnormal structure, shape and organization.[2] The permeability of those blood vessels is high and very variable in space and time.[3, 4] This abnormal permeability and aberrant morphologic vascularnetworkare associated with abnormal - blood flow, oxygen and nutrients delivery, and also decreased delivery of applied systemic medications.[5] The microenviorment of the tumor has zones of hypoxia, interstitial hypertension and necrosis.[6, 7, 8, 9, 10] According to Hobbs et al., when the tumor’diameter reaches 1-2mm,the integrity of blood brain barrier (BBB) is structurally and functionally impaired. The abnormal permeability and еfflux can be visualized on MRI/CT scan imaging as enchancement of the contrast. |
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| ISSN: | 2535-0765 |