The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial
Background and objective: The effect of preoperative magnetic resonance imaging (MRI) on long-term oncological outcomes following robot-assisted laparoscopic prostatectomy (RALP) is uncertain. The objective was to investigate the effect of preoperative MRI on long-term oncological outcomes after RAL...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | European Urology Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666168325002538 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849396373914386432 |
|---|---|
| author | Daniyal Noor Eduard Baco Peter M. Lauritzen Viktor Berge Kristina F. Galtung Maciej Jacewicz Lars Magne Eri Erik Rud |
| author_facet | Daniyal Noor Eduard Baco Peter M. Lauritzen Viktor Berge Kristina F. Galtung Maciej Jacewicz Lars Magne Eri Erik Rud |
| author_sort | Daniyal Noor |
| collection | DOAJ |
| description | Background and objective: The effect of preoperative magnetic resonance imaging (MRI) on long-term oncological outcomes following robot-assisted laparoscopic prostatectomy (RALP) is uncertain. The objective was to investigate the effect of preoperative MRI on long-term oncological outcomes after RALP. Methods: A single-institution follow-up study of a randomized controlled trial was conducted, which included 438 patients with biopsy-confirmed prostate cancer scheduled for RALP between December 2009 and June 2012 (NCT06429878). No patients underwent MRI prior to biopsy. Patients were randomized into two groups: one without MRI (n = 216) and one with preoperative MRI (n = 222). The primary endpoints were disease-free (DFS) and overall (OS) survival. The effect of MRI on these endpoints was estimated using hazard ratios (HRs) with 95% confidence intervals (CIs). Key findings and limitations: The median age was 63 yr (interquartile range [IQR] 59–67), and the median prostate-specific antigen level was 7.9 ng/ml (IQR 5.9–11.4). Based on D’Amico risk classification, 112 patients were at a low risk, 220 at an intermediate risk, and 106 at a high risk. The median follow-up was 111 mo (95% CI: 104–118). The 12-yr DFS rate was 60% (95% CI: 54–65) and OS rate was 87% (95% CI: 84–90). Preoperative MRI did not improve DFS (HR 0.97, 95% CI: 0.71–1.34) or OS (HR 0.86, 95% CI: 0.52–1.40), with similar findings across clinical subgroups. Limitations include the following: oncological outcomes were secondary endpoints and MRI pathway has undergone changes since the trial. Conclusions and clinical implications: During a 12-yr follow-up after RALP, we did not observe a statistically significant difference in DFS or OS between patients who underwent preoperative MRI and those who did not. These findings highlight the need to assess the long-term impact of prebiopsy MRI. Patient summary: We studied whether having a magnetic resonance imaging (MRI) scan before prostate cancer surgery improves long-term outcomes. A total of 438 men with prostate cancer were included in this study and they were divided into two groups: one without MRI and one with MRI before surgery. The patients were followed for up to 12 yr, and we found no clear reduction in the risk of cancer recurrence or improved survival in patients who had undergone MRI. Today, MRI is performed routinely before biopsy, and more research is needed to evaluate whether this change has improved long-term outcomes. |
| format | Article |
| id | doaj-art-c217622ba6d54cc89e98b5ef5ee8d5b8 |
| institution | Kabale University |
| issn | 2666-1683 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Urology Open Science |
| spelling | doaj-art-c217622ba6d54cc89e98b5ef5ee8d5b82025-08-20T03:39:21ZengElsevierEuropean Urology Open Science2666-16832025-09-0179798610.1016/j.euros.2025.07.005The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled TrialDaniyal Noor0Eduard Baco1Peter M. Lauritzen2Viktor Berge3Kristina F. Galtung4Maciej Jacewicz5Lars Magne Eri6Erik Rud7Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Corresponding author. Oslo University Hospital, Box 4959, Nydalen, 0424 Oslo, Norway. Tel. +47 995 02 437.Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Urology, Oslo University Hospital, Oslo, NorwayDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Department of Life Sciences and Health, Faculty of Health Science, Oslo Metropolitan University, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Urology, Oslo University Hospital, Oslo, NorwayDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Urology, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Urology, Oslo University Hospital, Oslo, NorwayDivision of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, NorwayBackground and objective: The effect of preoperative magnetic resonance imaging (MRI) on long-term oncological outcomes following robot-assisted laparoscopic prostatectomy (RALP) is uncertain. The objective was to investigate the effect of preoperative MRI on long-term oncological outcomes after RALP. Methods: A single-institution follow-up study of a randomized controlled trial was conducted, which included 438 patients with biopsy-confirmed prostate cancer scheduled for RALP between December 2009 and June 2012 (NCT06429878). No patients underwent MRI prior to biopsy. Patients were randomized into two groups: one without MRI (n = 216) and one with preoperative MRI (n = 222). The primary endpoints were disease-free (DFS) and overall (OS) survival. The effect of MRI on these endpoints was estimated using hazard ratios (HRs) with 95% confidence intervals (CIs). Key findings and limitations: The median age was 63 yr (interquartile range [IQR] 59–67), and the median prostate-specific antigen level was 7.9 ng/ml (IQR 5.9–11.4). Based on D’Amico risk classification, 112 patients were at a low risk, 220 at an intermediate risk, and 106 at a high risk. The median follow-up was 111 mo (95% CI: 104–118). The 12-yr DFS rate was 60% (95% CI: 54–65) and OS rate was 87% (95% CI: 84–90). Preoperative MRI did not improve DFS (HR 0.97, 95% CI: 0.71–1.34) or OS (HR 0.86, 95% CI: 0.52–1.40), with similar findings across clinical subgroups. Limitations include the following: oncological outcomes were secondary endpoints and MRI pathway has undergone changes since the trial. Conclusions and clinical implications: During a 12-yr follow-up after RALP, we did not observe a statistically significant difference in DFS or OS between patients who underwent preoperative MRI and those who did not. These findings highlight the need to assess the long-term impact of prebiopsy MRI. Patient summary: We studied whether having a magnetic resonance imaging (MRI) scan before prostate cancer surgery improves long-term outcomes. A total of 438 men with prostate cancer were included in this study and they were divided into two groups: one without MRI and one with MRI before surgery. The patients were followed for up to 12 yr, and we found no clear reduction in the risk of cancer recurrence or improved survival in patients who had undergone MRI. Today, MRI is performed routinely before biopsy, and more research is needed to evaluate whether this change has improved long-term outcomes.http://www.sciencedirect.com/science/article/pii/S2666168325002538Magnetic resonance imagingProstatectomyProstatic neoplasmsRandomized controlled trials as topicRecurrenceSurvival rate |
| spellingShingle | Daniyal Noor Eduard Baco Peter M. Lauritzen Viktor Berge Kristina F. Galtung Maciej Jacewicz Lars Magne Eri Erik Rud The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial European Urology Open Science Magnetic resonance imaging Prostatectomy Prostatic neoplasms Randomized controlled trials as topic Recurrence Survival rate |
| title | The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial |
| title_full | The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial |
| title_fullStr | The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial |
| title_full_unstemmed | The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial |
| title_short | The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial |
| title_sort | effect of preoperative magnetic resonance imaging on long term oncological outcomes following radical prostatectomy a 12 year follow up of a randomized controlled trial |
| topic | Magnetic resonance imaging Prostatectomy Prostatic neoplasms Randomized controlled trials as topic Recurrence Survival rate |
| url | http://www.sciencedirect.com/science/article/pii/S2666168325002538 |
| work_keys_str_mv | AT daniyalnoor theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT eduardbaco theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT petermlauritzen theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT viktorberge theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT kristinafgaltung theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT maciejjacewicz theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT larsmagneeri theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT erikrud theeffectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT daniyalnoor effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT eduardbaco effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT petermlauritzen effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT viktorberge effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT kristinafgaltung effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT maciejjacewicz effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT larsmagneeri effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial AT erikrud effectofpreoperativemagneticresonanceimagingonlongtermoncologicaloutcomesfollowingradicalprostatectomya12yearfollowupofarandomizedcontrolledtrial |