Cerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant Acinetobacter baumannii ventriculitis treated with intrathecal and intravenous polymyxin B

Cerebrospinal fluid proteomics reveals the innate immunity and blood-brain barrier dysregulation in a patient with multidrug-resistant Acinetobacter baumannii ventriculitis treated with intrathecal and intravenous polymyxin B

Acinetobacter baumannii is a major pathogen of nosocomial meningitis and ventriculitis. Due to very limited antibiotic treatment options, polymyxins are often used as a last-line therapy. To optimise polymyxin use in the intraventricular environment, cerebrospinal fluid (CSF) proteomics was employed...

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Bibliographic Details
Main Authors: Mengyao Li, Dongyu Liu, Phillip J. Bergen, Silin Liang, Juan Chen, Zhi Ying Kho, Jing Lu, Huiying Sun, Weiqing Hong, Xiaofen Liu, Chengying Hong, Youlian Chen, Wei Li, Hongxia You, Shunyao Xu, Yu Wang, Huaiji Gao, Chun Hin Lam, Jian Li, Xiaoyin Chen, Xueyan Liu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Cerebrospinal fluid
Proteomics
Acinetobacter baumannii
Ventriculitis
Polymyxin B
Intrathecal and intravenous administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024169241
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