Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization
The left and right sides of the brain show anatomical, neurochemical and functional differences. In the past century, brain and behavior lateralization was considered a human peculiarity associated with language and handedness. However, nowadays lateralization is known to occur among all vertebrates...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1527572/full |
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| _version_ | 1832593957585944576 |
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| author | Alessandra Gobbo Andrea Messina Giorgio Vallortigara |
| author_facet | Alessandra Gobbo Andrea Messina Giorgio Vallortigara |
| author_sort | Alessandra Gobbo |
| collection | DOAJ |
| description | The left and right sides of the brain show anatomical, neurochemical and functional differences. In the past century, brain and behavior lateralization was considered a human peculiarity associated with language and handedness. However, nowadays lateralization is known to occur among all vertebrates, from primates to fish. Fish, especially zebrafish (Danio rerio), have emerged as a crucial model for exploring the evolution and mechanisms of brain asymmetry. This review summarizes recent advances in zebrafish research on brain lateralization, highlighting how genetic tools, imaging, and transgenic methods have been used to investigate left–right asymmetries and their impact on sensory, cognitive, and social behaviors including possible links to neurodevelopmental and neurodegenerative disorders. |
| format | Article |
| id | doaj-art-c210efb945894f9aad1db9dbd6d25e02 |
| institution | Kabale University |
| issn | 1662-5153 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj-art-c210efb945894f9aad1db9dbd6d25e022025-01-20T07:20:19ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532025-01-011910.3389/fnbeh.2025.15275721527572Swimming through asymmetry: zebrafish as a model for brain and behavior lateralizationAlessandra GobboAndrea MessinaGiorgio VallortigaraThe left and right sides of the brain show anatomical, neurochemical and functional differences. In the past century, brain and behavior lateralization was considered a human peculiarity associated with language and handedness. However, nowadays lateralization is known to occur among all vertebrates, from primates to fish. Fish, especially zebrafish (Danio rerio), have emerged as a crucial model for exploring the evolution and mechanisms of brain asymmetry. This review summarizes recent advances in zebrafish research on brain lateralization, highlighting how genetic tools, imaging, and transgenic methods have been used to investigate left–right asymmetries and their impact on sensory, cognitive, and social behaviors including possible links to neurodevelopmental and neurodegenerative disorders.https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1527572/fullbehavioral lateralizationbrain asymmetrygeneticsDanio rerioneurodevelomental disorders |
| spellingShingle | Alessandra Gobbo Andrea Messina Giorgio Vallortigara Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization Frontiers in Behavioral Neuroscience behavioral lateralization brain asymmetry genetics Danio rerio neurodevelomental disorders |
| title | Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization |
| title_full | Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization |
| title_fullStr | Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization |
| title_full_unstemmed | Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization |
| title_short | Swimming through asymmetry: zebrafish as a model for brain and behavior lateralization |
| title_sort | swimming through asymmetry zebrafish as a model for brain and behavior lateralization |
| topic | behavioral lateralization brain asymmetry genetics Danio rerio neurodevelomental disorders |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1527572/full |
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