Identification of non-volatile components and anti-fatigue effect of a compound Lujiu
The non-volatile compounds in a compound Lujiu (38%vol) was detected by high-performance liquid chromatography quadrupole time-of- flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS). The compound Lujiu was intragastric administered to mice for 22 d to investigate its effect on weight-bearing swimmin...
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Editorial Department of China Brewing
2024-08-01
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| Series: | Zhongguo niangzao |
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| Online Access: | https://manu61.magtech.com.cn/zgnz/fileup/0254-5071/PDF/0254-5071-2024-43-8-86.pdf |
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| author | CHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping |
| author_facet | CHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping |
| author_sort | CHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping |
| collection | DOAJ |
| description | The non-volatile compounds in a compound Lujiu (38%vol) was detected by high-performance liquid chromatography quadrupole time-of- flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS). The compound Lujiu was intragastric administered to mice for 22 d to investigate its effect on weight-bearing swimming and evaluate its anti-fatigue health benefits. The results showed that a total of 52 non-volatile substances were identified from the compound Lujiu (0.225 7 g crude drug/ml), including 24 saponins, 6 flavonoids, 4 nucleosides, 4 amino acids, 3 alkaloids, and 11 others. Compared with the model group, the body weight reduction of mice in the low, medium and high dose groups was significantly reduced (P<0.01), the weight-bearing swimming time of mice in the medium and high dose groups was significantly prolonged (P<0.01), the content of blood urea nitrogen (BUN) of mice in low and medium dose groups was significantly increased (P<0.01, P<0.05), the activity of lactate dehydrogenase (LDH) and the content of liver glycogen (LG) of mice in the low, medium and high dose groups were significantly increased (P<0.01, P<0.05), indicating that the compound Lujiu was rich in non-volatile substances, which could enhance the body's adaptability to load and had a significant anti-fatigue effect, providing a certain foundation for the development of functional foods. |
| format | Article |
| id | doaj-art-c20cbdf44668419b89f372c35b9cff8a |
| institution | OA Journals |
| issn | 0254-5071 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Editorial Department of China Brewing |
| record_format | Article |
| series | Zhongguo niangzao |
| spelling | doaj-art-c20cbdf44668419b89f372c35b9cff8a2025-08-20T02:11:05ZengEditorial Department of China BrewingZhongguo niangzao0254-50712024-08-01438869210.11882/j.issn.0254-5071.2024.08.013Identification of non-volatile components and anti-fatigue effect of a compound LujiuCHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping01. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; ;2. Jiangsu Yanghe Brewery Joint-Stock Co., Ltd., Suqian 223800, China; ;3. National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Lianyungang 222047, ChinaThe non-volatile compounds in a compound Lujiu (38%vol) was detected by high-performance liquid chromatography quadrupole time-of- flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS). The compound Lujiu was intragastric administered to mice for 22 d to investigate its effect on weight-bearing swimming and evaluate its anti-fatigue health benefits. The results showed that a total of 52 non-volatile substances were identified from the compound Lujiu (0.225 7 g crude drug/ml), including 24 saponins, 6 flavonoids, 4 nucleosides, 4 amino acids, 3 alkaloids, and 11 others. Compared with the model group, the body weight reduction of mice in the low, medium and high dose groups was significantly reduced (P<0.01), the weight-bearing swimming time of mice in the medium and high dose groups was significantly prolonged (P<0.01), the content of blood urea nitrogen (BUN) of mice in low and medium dose groups was significantly increased (P<0.01, P<0.05), the activity of lactate dehydrogenase (LDH) and the content of liver glycogen (LG) of mice in the low, medium and high dose groups were significantly increased (P<0.01, P<0.05), indicating that the compound Lujiu was rich in non-volatile substances, which could enhance the body's adaptability to load and had a significant anti-fatigue effect, providing a certain foundation for the development of functional foods.https://manu61.magtech.com.cn/zgnz/fileup/0254-5071/PDF/0254-5071-2024-43-8-86.pdfcompound lujiu|high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry|non-volatile composition|anti-fatigue |
| spellingShingle | CHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping Identification of non-volatile components and anti-fatigue effect of a compound Lujiu Zhongguo niangzao compound lujiu|high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry|non-volatile composition|anti-fatigue |
| title | Identification of non-volatile components and anti-fatigue effect of a compound Lujiu |
| title_full | Identification of non-volatile components and anti-fatigue effect of a compound Lujiu |
| title_fullStr | Identification of non-volatile components and anti-fatigue effect of a compound Lujiu |
| title_full_unstemmed | Identification of non-volatile components and anti-fatigue effect of a compound Lujiu |
| title_short | Identification of non-volatile components and anti-fatigue effect of a compound Lujiu |
| title_sort | identification of non volatile components and anti fatigue effect of a compound lujiu |
| topic | compound lujiu|high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry|non-volatile composition|anti-fatigue |
| url | https://manu61.magtech.com.cn/zgnz/fileup/0254-5071/PDF/0254-5071-2024-43-8-86.pdf |
| work_keys_str_mv | AT chenyingzhuyuzheyumeililiufangmeilicunyuzhengyunfengpengguoping identificationofnonvolatilecomponentsandantifatigueeffectofacompoundlujiu |