Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness
IntroductionThe application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs, but often resu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485549/full |
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| author | Xuran Zhang Xuran Zhang Jian Wang Qun Feng Li Lei Zhiyong Zhu |
| author_facet | Xuran Zhang Xuran Zhang Jian Wang Qun Feng Li Lei Zhiyong Zhu |
| author_sort | Xuran Zhang |
| collection | DOAJ |
| description | IntroductionThe application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs, but often result in aggregation-caused quenching (ACQ) effects, preventing site-specific activation.MethodsWe exploited manganese (Mn2+)–pyrochloric acid (PPa) nanocomplexes coordinated using the photosensitizer PPa and metal Mn ion for the treatment of osteosarcoma. The nanocomplexes were precisely co-assembled in water to stably co-deliver Mn2+ and PPa, enabling tumor-specific release and fluorescence recovery.ResultsFollowing laser irradiation, the activated PPa significantly enhanced the killing effects on primary cancer cells. Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy. |
| format | Article |
| id | doaj-art-c20ae28d066f468badf7fdf4c88c4261 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-c20ae28d066f468badf7fdf4c88c42612025-02-11T04:11:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011210.3389/fbioe.2024.14855491485549Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectivenessXuran Zhang0Xuran Zhang1Jian Wang2Qun Feng3Li Lei4Zhiyong Zhu5Department of Orthopedics, Fuxin Center Hospital, Fuxin, ChinaDepartment of Sports Medicine and Joint Surgery, The People’s Hospital of Liaoning Province, Shenyang, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, ChinaDepartment of Sports Medicine and Joint Surgery, The People’s Hospital of Liaoning Province, Shenyang, ChinaDepartment of Pathology, Fuxin Center Hospital, Fuxin, ChinaDepartment of Sports Medicine and Joint Surgery, The People’s Hospital of Liaoning Province, Shenyang, ChinaIntroductionThe application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. Intravenous nano-drug delivery systems (NDDSs) hold promise for enhancing the delivery efficiency of photosensitive drugs, but often result in aggregation-caused quenching (ACQ) effects, preventing site-specific activation.MethodsWe exploited manganese (Mn2+)–pyrochloric acid (PPa) nanocomplexes coordinated using the photosensitizer PPa and metal Mn ion for the treatment of osteosarcoma. The nanocomplexes were precisely co-assembled in water to stably co-deliver Mn2+ and PPa, enabling tumor-specific release and fluorescence recovery.ResultsFollowing laser irradiation, the activated PPa significantly enhanced the killing effects on primary cancer cells. Additionally, Mn2+ ions activated the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, promoting maturation of dendritic cells (DCs) and augmenting CD8+-mediated antitumor immune responses.DiscussionThis study advances the on-demand activation of photosensitive drugs and photodynamic immunotherapy toward clinical applicability by exploiting Mn2+–PPa nanocomplexes with high activatability and effectiveness for targeted PDT and immunotherapy.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485549/fullphotodynamic therapynano-drug delivery systemsmanganese-pyrochloric acid nanocomplexesboth high activatability and high effectivenessosteosarcoma |
| spellingShingle | Xuran Zhang Xuran Zhang Jian Wang Qun Feng Li Lei Zhiyong Zhu Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness Frontiers in Bioengineering and Biotechnology photodynamic therapy nano-drug delivery systems manganese-pyrochloric acid nanocomplexes both high activatability and high effectiveness osteosarcoma |
| title | Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness |
| title_full | Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness |
| title_fullStr | Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness |
| title_full_unstemmed | Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness |
| title_short | Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness |
| title_sort | manganese pyrochloric acid photosensitizer nanocomplexes against osteosarcoma achieving both high activatability and high effectiveness |
| topic | photodynamic therapy nano-drug delivery systems manganese-pyrochloric acid nanocomplexes both high activatability and high effectiveness osteosarcoma |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1485549/full |
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