Allergic rhinoconjunctivitis (a tool to help clinicians)
Allergic rhinoconjunctivitis is a chronic inflammatory IgE-mediated reaction to relevant allergens encountering nasal mucosa and conjunctiva. Allergen-specific IgE binds to high-affinity Fcε receptors (Fcε RI) expressed by ocular and nasal mast cells. Therefore, nasal mucosa and conjunctiva have com...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2014-10-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/196 |
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| author | N. A. Aref’eva V. V. Brzheskii V. V. Vishnyakov A. V. Emel’yanov S. A. Karpishchenko S. Ya. Kosyakov A. S. Lopatin D. Yu. Maichuk Ya. A. Nakatis I. V. Otvagin G. Z. Piskunov D. P. Polyakov |
| author_facet | N. A. Aref’eva V. V. Brzheskii V. V. Vishnyakov A. V. Emel’yanov S. A. Karpishchenko S. Ya. Kosyakov A. S. Lopatin D. Yu. Maichuk Ya. A. Nakatis I. V. Otvagin G. Z. Piskunov D. P. Polyakov |
| author_sort | N. A. Aref’eva |
| collection | DOAJ |
| description | Allergic rhinoconjunctivitis is a chronic inflammatory IgE-mediated reaction to relevant allergens encountering nasal mucosa and conjunctiva. Allergen-specific IgE binds to high-affinity Fcε receptors (Fcε RI) expressed by ocular and nasal mast cells. Therefore, nasal mucosa and conjunctiva have common mechanisms of antigen recognition. Detailed clinical history and examination provide correct diagnosis, relevant allergen identification, symptom severity assessment, and therapeutic algorithm. Recently, an assay for the measurement of specific IgE antibodies against numerous (120) allergens in human blood, ImmunoCAP, was developed. Conventional allergic rhinoconjunctivitis treatment includes allergen avoidance, pharmacotherapy, and allergen-specific immune therapy. Four major classes of drugs are used for the treatment, i.e., antihistamines, corticosteroids, mast cell stabilizers, and vasoconstrictor agents (or decongestants). Occasionally, muscarinic receptor antagonists, antileukotrienes, and immunemodulators are used. Therapeutic strategy is determined by the effect of a drug on certain symptoms and allergy clinical course, adverse reaction and complication risks, age limitations, and costs. Stepwise approach to the treatment of allergic rhinoconjunctivitis should be based onsymptom severity. Full-text clinical guidelines are available on the official website of Russian Rhinologic Society (http://www.rhinology.ru / index1. php?id_page = 3&id_text2 = 43&num_text2 = 1). |
| format | Article |
| id | doaj-art-c20621c2e6284366a5dfaaf1f1e1ea52 |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2014-10-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-c20621c2e6284366a5dfaaf1f1e1ea522025-08-20T04:00:20ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452014-10-011139410310.18008/1816-5095-2014-3-94-103196Allergic rhinoconjunctivitis (a tool to help clinicians)N. A. Aref’eva0V. V. Brzheskii1V. V. Vishnyakov2A. V. Emel’yanov3S. A. Karpishchenko4S. Ya. Kosyakov5A. S. Lopatin6D. Yu. Maichuk7Ya. A. Nakatis8I. V. Otvagin9G. Z. Piskunov10D. P. Polyakov11Башкирский государственный медицинский университетСанкт-Петербургский государственный педиатрический медицинский университетМосковский государственный медицинский стоматологический университетСеверо-Западный государственный медицинский университет им. И. И . М ечниковаПервый Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаРоссийская медицинская академия последипломного образованияПоликлиника № 1 УД Президента РФМНТ К «Микрохирургия глаза им. акад. С. Н . Федорова»Клиническая больница № 122 им. Соколова ФМБА России, Санкт-ПетербургГБОУ ВПО Смоленская государственная медицинская академияРоссийская медицинская академия последипломного образованияНаучный центр здоровья детей РАМНAllergic rhinoconjunctivitis is a chronic inflammatory IgE-mediated reaction to relevant allergens encountering nasal mucosa and conjunctiva. Allergen-specific IgE binds to high-affinity Fcε receptors (Fcε RI) expressed by ocular and nasal mast cells. Therefore, nasal mucosa and conjunctiva have common mechanisms of antigen recognition. Detailed clinical history and examination provide correct diagnosis, relevant allergen identification, symptom severity assessment, and therapeutic algorithm. Recently, an assay for the measurement of specific IgE antibodies against numerous (120) allergens in human blood, ImmunoCAP, was developed. Conventional allergic rhinoconjunctivitis treatment includes allergen avoidance, pharmacotherapy, and allergen-specific immune therapy. Four major classes of drugs are used for the treatment, i.e., antihistamines, corticosteroids, mast cell stabilizers, and vasoconstrictor agents (or decongestants). Occasionally, muscarinic receptor antagonists, antileukotrienes, and immunemodulators are used. Therapeutic strategy is determined by the effect of a drug on certain symptoms and allergy clinical course, adverse reaction and complication risks, age limitations, and costs. Stepwise approach to the treatment of allergic rhinoconjunctivitis should be based onsymptom severity. Full-text clinical guidelines are available on the official website of Russian Rhinologic Society (http://www.rhinology.ru / index1. php?id_page = 3&id_text2 = 43&num_text2 = 1).https://www.ophthalmojournal.com/opht/article/view/196риноконъюнктивиталлергияфармакотерапия |
| spellingShingle | N. A. Aref’eva V. V. Brzheskii V. V. Vishnyakov A. V. Emel’yanov S. A. Karpishchenko S. Ya. Kosyakov A. S. Lopatin D. Yu. Maichuk Ya. A. Nakatis I. V. Otvagin G. Z. Piskunov D. P. Polyakov Allergic rhinoconjunctivitis (a tool to help clinicians) Oftalʹmologiâ риноконъюнктивит аллергия фармакотерапия |
| title | Allergic rhinoconjunctivitis (a tool to help clinicians) |
| title_full | Allergic rhinoconjunctivitis (a tool to help clinicians) |
| title_fullStr | Allergic rhinoconjunctivitis (a tool to help clinicians) |
| title_full_unstemmed | Allergic rhinoconjunctivitis (a tool to help clinicians) |
| title_short | Allergic rhinoconjunctivitis (a tool to help clinicians) |
| title_sort | allergic rhinoconjunctivitis a tool to help clinicians |
| topic | риноконъюнктивит аллергия фармакотерапия |
| url | https://www.ophthalmojournal.com/opht/article/view/196 |
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