Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution
Rhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. Our analysis furt...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2019/8987436 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564709190008832 |
|---|---|
| author | Jianchao Ying Jun Ye Teng Xu Qian Wang Qiyu Bao Aifang Li |
| author_facet | Jianchao Ying Jun Ye Teng Xu Qian Wang Qiyu Bao Aifang Li |
| author_sort | Jianchao Ying |
| collection | DOAJ |
| description | Rhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. Our analysis further showed that the core genome of R. equi contributes to the pathogenicity and niche adaptation of R. equi. Comparative genomic analysis revealed that the genomes of R. equi shared identical collinearity relationship, and heterogeneity was mainly acquired by means of genomic islands and prophages. Moreover, genomic islands in R. equi were always involved in virulence, resistance, or niche adaptation and possibly working with prophages to cause the majority of genome expansion. These findings provide an insight into the genomic diversity, evolution, and structural variation of R. equi and a valuable resource for functional genomic studies. |
| format | Article |
| id | doaj-art-c20209205f2b4b9c825a212961183053 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-c20209205f2b4b9c825a2129611830532025-02-03T01:10:25ZengWileyInternational Journal of Genomics2314-436X2314-43782019-01-01201910.1155/2019/89874368987436Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome EvolutionJianchao Ying0Jun Ye1Teng Xu2Qian Wang3Qiyu Bao4Aifang Li5Central Laboratory, Institute of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Guizhou Medical University, Kaili, ChinaInstitute of Translational Medicine, Baotou Central Clinical Hospital of Inner Mogolia Medical University, Baotou, ChinaDepartment of Clinical Laboratory, Wenzhou People’s Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, ChinaThe Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, ChinaRhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. Our analysis further showed that the core genome of R. equi contributes to the pathogenicity and niche adaptation of R. equi. Comparative genomic analysis revealed that the genomes of R. equi shared identical collinearity relationship, and heterogeneity was mainly acquired by means of genomic islands and prophages. Moreover, genomic islands in R. equi were always involved in virulence, resistance, or niche adaptation and possibly working with prophages to cause the majority of genome expansion. These findings provide an insight into the genomic diversity, evolution, and structural variation of R. equi and a valuable resource for functional genomic studies.http://dx.doi.org/10.1155/2019/8987436 |
| spellingShingle | Jianchao Ying Jun Ye Teng Xu Qian Wang Qiyu Bao Aifang Li Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution International Journal of Genomics |
| title | Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution |
| title_full | Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution |
| title_fullStr | Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution |
| title_full_unstemmed | Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution |
| title_short | Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution |
| title_sort | comparative genomic analysis of rhodococcus equi an insight into genomic diversity and genome evolution |
| url | http://dx.doi.org/10.1155/2019/8987436 |
| work_keys_str_mv | AT jianchaoying comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution AT junye comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution AT tengxu comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution AT qianwang comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution AT qiyubao comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution AT aifangli comparativegenomicanalysisofrhodococcusequianinsightintogenomicdiversityandgenomeevolution |