Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects
The application background of mussel-inspired materials is based on the unique underwater adhesive ability of marine mussels, which has inspired researchers to develop bionic materials with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-di...
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MDPI AG
2025-03-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/10/4/206 |
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| author | Yanai Chen Yijia Cao Pengyu Cui Shenzhou Lu |
| author_facet | Yanai Chen Yijia Cao Pengyu Cui Shenzhou Lu |
| author_sort | Yanai Chen |
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| description | The application background of mussel-inspired materials is based on the unique underwater adhesive ability of marine mussels, which has inspired researchers to develop bionic materials with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus is able to form non-covalent forces on a variety of surfaces, which are critical for the mussel’s underwater adhesion and enable the mussel-inspired material to dissipate energy and repair itself under external forces. Mussel-inspired hydrogels are ideal medical adhesive materials due to their unique physical and chemical properties, such as excellent tissue adhesion, hemostasis and bacteriostasis, biosafety, and plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, and other biomedical materials and discussed the advanced functions of mussel-inspired hydrogels as wound dressings, including antibacterial, anti-inflammatory, and antioxidant properties, adhesion and hemostasis, material transport, self-healing, stimulating response, and so on. At the same time, the technical challenges and limitations of the biomimetic mussel hydrogel in biomedical applications were further discussed, and its potential solutions and future research developments in the field of biomedicine were highlighted. |
| format | Article |
| id | doaj-art-c1fe2205755e4abb893af2f72264b3bf |
| institution | OA Journals |
| issn | 2313-7673 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Biomimetics |
| spelling | doaj-art-c1fe2205755e4abb893af2f72264b3bf2025-08-20T02:17:25ZengMDPI AGBiomimetics2313-76732025-03-0110420610.3390/biomimetics10040206Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future ProspectsYanai Chen0Yijia Cao1Pengyu Cui2Shenzhou Lu3National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaNational Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, ChinaThe application background of mussel-inspired materials is based on the unique underwater adhesive ability of marine mussels, which has inspired researchers to develop bionic materials with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus is able to form non-covalent forces on a variety of surfaces, which are critical for the mussel’s underwater adhesion and enable the mussel-inspired material to dissipate energy and repair itself under external forces. Mussel-inspired hydrogels are ideal medical adhesive materials due to their unique physical and chemical properties, such as excellent tissue adhesion, hemostasis and bacteriostasis, biosafety, and plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, and other biomedical materials and discussed the advanced functions of mussel-inspired hydrogels as wound dressings, including antibacterial, anti-inflammatory, and antioxidant properties, adhesion and hemostasis, material transport, self-healing, stimulating response, and so on. At the same time, the technical challenges and limitations of the biomimetic mussel hydrogel in biomedical applications were further discussed, and its potential solutions and future research developments in the field of biomedicine were highlighted.https://www.mdpi.com/2313-7673/10/4/206mussel-inspiredhydrogelwound healing |
| spellingShingle | Yanai Chen Yijia Cao Pengyu Cui Shenzhou Lu Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects Biomimetics mussel-inspired hydrogel wound healing |
| title | Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects |
| title_full | Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects |
| title_fullStr | Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects |
| title_full_unstemmed | Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects |
| title_short | Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects |
| title_sort | mussel inspired hydrogel applied to wound healing a review and future prospects |
| topic | mussel-inspired hydrogel wound healing |
| url | https://www.mdpi.com/2313-7673/10/4/206 |
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