Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure
Abstract This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | npj Biological Timing and Sleep |
| Online Access: | https://doi.org/10.1038/s44323-025-00045-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343474497748992 |
|---|---|
| author | Valérie Mongrain Marcos G. Frank Tanya Leduc |
| author_facet | Valérie Mongrain Marcos G. Frank Tanya Leduc |
| author_sort | Valérie Mongrain |
| collection | DOAJ |
| description | Abstract This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with development/aging are also emphasized. We suggest the concept of sleep homeostasis to be regarded as a variety of homeostats (not a single one) serving different functions for the brain across the lifespan. |
| format | Article |
| id | doaj-art-c1faadfadccd4b6da9208a49a34a2c96 |
| institution | Kabale University |
| issn | 2948-281X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biological Timing and Sleep |
| spelling | doaj-art-c1faadfadccd4b6da9208a49a34a2c962025-08-20T03:42:57ZengNature Portfolionpj Biological Timing and Sleep2948-281X2025-08-01211810.1038/s44323-025-00045-1Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressureValérie Mongrain0Marcos G. Frank1Tanya Leduc2Department of Neuroscience, Université de MontréalDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State UniversityDepartment of Neuroscience, Université de MontréalAbstract This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with development/aging are also emphasized. We suggest the concept of sleep homeostasis to be regarded as a variety of homeostats (not a single one) serving different functions for the brain across the lifespan.https://doi.org/10.1038/s44323-025-00045-1 |
| spellingShingle | Valérie Mongrain Marcos G. Frank Tanya Leduc Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure npj Biological Timing and Sleep |
| title | Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| title_full | Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| title_fullStr | Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| title_full_unstemmed | Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| title_short | Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| title_sort | revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure |
| url | https://doi.org/10.1038/s44323-025-00045-1 |
| work_keys_str_mv | AT valeriemongrain revisitingbraingeneexpressionchangesandproteinmodificationstrackinghomeostaticsleeppressure AT marcosgfrank revisitingbraingeneexpressionchangesandproteinmodificationstrackinghomeostaticsleeppressure AT tanyaleduc revisitingbraingeneexpressionchangesandproteinmodificationstrackinghomeostaticsleeppressure |