A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness
This study presents a comprehensive genomic reanalysis of major bacterial pathogens causing bovine mastitis and lameness, focusing on <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Fusobacterium necrophorum</i>, and <i>Treponema phagedenis</i&g...
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MDPI AG
2025-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/15/3/394 |
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| author | Szilvia Kusza Zoltán Bagi |
| author_facet | Szilvia Kusza Zoltán Bagi |
| author_sort | Szilvia Kusza |
| collection | DOAJ |
| description | This study presents a comprehensive genomic reanalysis of major bacterial pathogens causing bovine mastitis and lameness, focusing on <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Fusobacterium necrophorum</i>, and <i>Treponema phagedenis</i>. Through our analysis of 4326 bacterial genomes from global databases, we identified distinct patterns in genomic diversity, virulence factors and antimicrobial resistance genes across these species. <i>E. coli</i> showed the highest genomic diversity with 3779 isolates, of which 98% exhibited high-quality genome sequences. Similarly, <i>S. aureus</i> demonstrated significant genomic plasticity across 524 isolates, with 99.8% classified as high-quality genomes. Geographical analysis revealed distinct regional variations in strain distribution, with North America contributing 45.3% of all isolates, followed by Asia (21.2%) and Europe (18.1%). Furthermore, we identified novel virulence mechanisms and resistance patterns specific to each pathogen, with particular emphasis on the evolution of antimicrobial resistance genes. Our findings provide crucial insights into pathogen adaptation and host–microbe interactions, suggesting the need for region-specific intervention strategies. These results have significant implications for developing targeted therapeutic approaches and improving bovine health management practices. |
| format | Article |
| id | doaj-art-c1f483fd0cbc4e359af0b42c74b1d903 |
| institution | DOAJ |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-c1f483fd0cbc4e359af0b42c74b1d9032025-08-20T02:48:01ZengMDPI AGAnimals2076-26152025-01-0115339410.3390/ani15030394A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and LamenessSzilvia Kusza0Zoltán Bagi1Centre for Agricultural Genomics and Biotechnology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, HungaryCentre for Agricultural Genomics and Biotechnology, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, HungaryThis study presents a comprehensive genomic reanalysis of major bacterial pathogens causing bovine mastitis and lameness, focusing on <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Fusobacterium necrophorum</i>, and <i>Treponema phagedenis</i>. Through our analysis of 4326 bacterial genomes from global databases, we identified distinct patterns in genomic diversity, virulence factors and antimicrobial resistance genes across these species. <i>E. coli</i> showed the highest genomic diversity with 3779 isolates, of which 98% exhibited high-quality genome sequences. Similarly, <i>S. aureus</i> demonstrated significant genomic plasticity across 524 isolates, with 99.8% classified as high-quality genomes. Geographical analysis revealed distinct regional variations in strain distribution, with North America contributing 45.3% of all isolates, followed by Asia (21.2%) and Europe (18.1%). Furthermore, we identified novel virulence mechanisms and resistance patterns specific to each pathogen, with particular emphasis on the evolution of antimicrobial resistance genes. Our findings provide crucial insights into pathogen adaptation and host–microbe interactions, suggesting the need for region-specific intervention strategies. These results have significant implications for developing targeted therapeutic approaches and improving bovine health management practices.https://www.mdpi.com/2076-2615/15/3/394animal healthbovinegenomicsmastitislameness |
| spellingShingle | Szilvia Kusza Zoltán Bagi A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness Animals animal health bovine genomics mastitis lameness |
| title | A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness |
| title_full | A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness |
| title_fullStr | A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness |
| title_full_unstemmed | A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness |
| title_short | A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness |
| title_sort | global comparative genomic analysis of major bacterial pathogens in bovine mastitis and lameness |
| topic | animal health bovine genomics mastitis lameness |
| url | https://www.mdpi.com/2076-2615/15/3/394 |
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