Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review
Evidence has shown that women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome have an increased risk of cardiovascular disease later in life. Recommendations for screening, prevention and management after such pregnancies are not yet defined. T...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-09-01
|
| Series: | European Cardiology Review |
| Online Access: | https://www.ecrjournal.com/articleindex/ecr.2021.21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850256465485365248 |
|---|---|
| author | Esmee ME Bovee Martha Gulati Angela HEM Maas |
| author_facet | Esmee ME Bovee Martha Gulati Angela HEM Maas |
| author_sort | Esmee ME Bovee |
| collection | DOAJ |
| description | Evidence has shown that women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome have an increased risk of cardiovascular disease later in life. Recommendations for screening, prevention and management after such pregnancies are not yet defined. The identification of promising non-traditional cardiovascular biomarkers might be useful to predict which women are at greatest risk. Many studies are inconsistent and an overview of the most promising biomarkers is currently lacking. This narrative review provides an update of the current literature on circulating cardiovascular biomarkers that may be associated with an increased cardiovascular disease risk in women after previous preeclampsia/HELLP syndrome. Fifty-six studies on 53 biomarkers were included. From the summary of evidence, soluble fms-like tyrosine kinase-1, placental growth factor, interleukin (IL)-6, IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A and norepinephrine show potential and are interesting candidate biomarkers to further explore. These biomarkers might be potentially eligible for cardiovascular risk stratification after preeclampsia/HELLP syndrome and may contribute to the development of adequate strategies for prevention of hypertension and adverse events in this population. |
| format | Article |
| id | doaj-art-c1f3a2bf47534202b416901e418169ec |
| institution | OA Journals |
| issn | 1758-3756 1758-3764 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | European Cardiology Review |
| spelling | doaj-art-c1f3a2bf47534202b416901e418169ec2025-08-20T01:56:38ZengRadcliffe Medical MediaEuropean Cardiology Review1758-37561758-37642021-09-011610.15420/ecr.2021.21Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative ReviewEsmee ME Bovee0Martha Gulati1Angela HEM Maas2Radboud University, Nijmegen, the NetherlandsUniversity of Arizona, Phoenix, Arizona, USDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the NetherlandsEvidence has shown that women with a history of preeclampsia or haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome have an increased risk of cardiovascular disease later in life. Recommendations for screening, prevention and management after such pregnancies are not yet defined. The identification of promising non-traditional cardiovascular biomarkers might be useful to predict which women are at greatest risk. Many studies are inconsistent and an overview of the most promising biomarkers is currently lacking. This narrative review provides an update of the current literature on circulating cardiovascular biomarkers that may be associated with an increased cardiovascular disease risk in women after previous preeclampsia/HELLP syndrome. Fifty-six studies on 53 biomarkers were included. From the summary of evidence, soluble fms-like tyrosine kinase-1, placental growth factor, interleukin (IL)-6, IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A and norepinephrine show potential and are interesting candidate biomarkers to further explore. These biomarkers might be potentially eligible for cardiovascular risk stratification after preeclampsia/HELLP syndrome and may contribute to the development of adequate strategies for prevention of hypertension and adverse events in this population.https://www.ecrjournal.com/articleindex/ecr.2021.21 |
| spellingShingle | Esmee ME Bovee Martha Gulati Angela HEM Maas Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review European Cardiology Review |
| title | Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review |
| title_full | Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review |
| title_fullStr | Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review |
| title_full_unstemmed | Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review |
| title_short | Novel Cardiovascular Biomarkers Associated with Increased Cardiovascular Risk in Women With Prior Preeclampsia/HELLP Syndrome: A Narrative Review |
| title_sort | novel cardiovascular biomarkers associated with increased cardiovascular risk in women with prior preeclampsia hellp syndrome a narrative review |
| url | https://www.ecrjournal.com/articleindex/ecr.2021.21 |
| work_keys_str_mv | AT esmeemebovee novelcardiovascularbiomarkersassociatedwithincreasedcardiovascularriskinwomenwithpriorpreeclampsiahellpsyndromeanarrativereview AT marthagulati novelcardiovascularbiomarkersassociatedwithincreasedcardiovascularriskinwomenwithpriorpreeclampsiahellpsyndromeanarrativereview AT angelahemmaas novelcardiovascularbiomarkersassociatedwithincreasedcardiovascularriskinwomenwithpriorpreeclampsiahellpsyndromeanarrativereview |