Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease
Programming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms. Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which m...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2018/8547976 |
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| _version_ | 1850176518039273472 |
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| author | Annelene Govindsamy Strinivasen Naidoo Marlon E. Cerf |
| author_facet | Annelene Govindsamy Strinivasen Naidoo Marlon E. Cerf |
| author_sort | Annelene Govindsamy |
| collection | DOAJ |
| description | Programming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms. Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which manifests as micro- and/or macrovascular complications due to diabetic complications. Cardiogenesis is a sequential process during which the heart develops into a mature organ and is regulated by several cardiac-specific transcription factors. Disrupted cardiac insulin signalling contributes to cardiac insulin resistance. Intrauterine under- or overnutrition alters offspring cardiac structure and function, notably cardiac hypertrophy, systolic and diastolic dysfunction, and hypertension that precede the onset of cardiovascular disease. Optimal intrauterine nutrition and oxygen saturation are required for normal cardiac development in offspring and the maintenance of their cardiovascular physiology. |
| format | Article |
| id | doaj-art-c1f2c0eb504f4353960f6c3a060baac5 |
| institution | OA Journals |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-c1f2c0eb504f4353960f6c3a060baac52025-08-20T02:19:15ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322018-01-01201810.1155/2018/85479768547976Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular DiseaseAnnelene Govindsamy0Strinivasen Naidoo1Marlon E. Cerf2Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South AfricaDiscipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, South AfricaBiomedical Research and Innovation Platform, South African Medical Research Council, Cape Town, South AfricaProgramming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms. Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which manifests as micro- and/or macrovascular complications due to diabetic complications. Cardiogenesis is a sequential process during which the heart develops into a mature organ and is regulated by several cardiac-specific transcription factors. Disrupted cardiac insulin signalling contributes to cardiac insulin resistance. Intrauterine under- or overnutrition alters offspring cardiac structure and function, notably cardiac hypertrophy, systolic and diastolic dysfunction, and hypertension that precede the onset of cardiovascular disease. Optimal intrauterine nutrition and oxygen saturation are required for normal cardiac development in offspring and the maintenance of their cardiovascular physiology.http://dx.doi.org/10.1155/2018/8547976 |
| spellingShingle | Annelene Govindsamy Strinivasen Naidoo Marlon E. Cerf Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease Journal of Nutrition and Metabolism |
| title | Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease |
| title_full | Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease |
| title_fullStr | Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease |
| title_full_unstemmed | Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease |
| title_short | Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease |
| title_sort | cardiac development and transcription factors insulin signalling insulin resistance and intrauterine nutritional programming of cardiovascular disease |
| url | http://dx.doi.org/10.1155/2018/8547976 |
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