Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension
ABSTRACT Introduction We aimed to explore the difference in choroidal vascular parameters using swept‐source optical coherence tomography (SS‐OCT) in patients with idiopathic intracranial hypertension (IIH) compared to controls. We also explored the ability of the choroidal parameters to reflect ele...
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70258 |
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| author | Hang Wang Rui Wang Le Cao William Robert Kwapong Ruishan Liu Fayun Hu Bo Wu |
| author_facet | Hang Wang Rui Wang Le Cao William Robert Kwapong Ruishan Liu Fayun Hu Bo Wu |
| author_sort | Hang Wang |
| collection | DOAJ |
| description | ABSTRACT Introduction We aimed to explore the difference in choroidal vascular parameters using swept‐source optical coherence tomography (SS‐OCT) in patients with idiopathic intracranial hypertension (IIH) compared to controls. We also explored the ability of the choroidal parameters to reflect elevated intracranial pressure (ICP) in patients with IIH. Methods This observational study recruited patients diagnosed with IIH and healthy controls. A lumbar puncture was performed for ICP measurement. All the participants underwent OCT examinations. The choroid was automatically segmented and imaged by the OCT tool. The parafoveal choroidal vascular volume (CVV) and choroidal vascular index (CVI) were calculated in 3 mm annulus and 6 mm annulus. Results A total of 80 patients with IIH (34.67 ± 11.00 years; 37.50% males) and 92 controls (34.50 ± 12.08 years; 36.96% males) were included in the final analysis. Patients with IIH had higher BMI (< 0.001) and poor visual acuity (< 0.001) compared with controls. Patients with IIH demonstrated significantly lower parafovea CVI in both annuluses (p = 0.003 for 3 mm annulus, p = 0.001 for 6 mm annulus) compared to controls. Mean parafovea CVI in both annuluses was significantly correlated with ICP level (p = 0.014 for 3 mm annulus, p = 0.015 for 6 mm annulus). The combination of CVV and CVI in a 6 mm annulus demonstrated the highest diagnostic value with a mean AUC of 0.818. Conclusion CVI may serve as a potential marker for identifying IIH and reflecting ICP changes. |
| format | Article |
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| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-c1f28f02cf2843cca59ef9736347ec562025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70258Decreased Choroidal Vascular Index in Idiopathic Intracranial HypertensionHang Wang0Rui Wang1Le Cao2William Robert Kwapong3Ruishan Liu4Fayun Hu5Bo Wu6Department of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaDepartment of Neurology, West China HospitalSichuan University Chengdu ChinaABSTRACT Introduction We aimed to explore the difference in choroidal vascular parameters using swept‐source optical coherence tomography (SS‐OCT) in patients with idiopathic intracranial hypertension (IIH) compared to controls. We also explored the ability of the choroidal parameters to reflect elevated intracranial pressure (ICP) in patients with IIH. Methods This observational study recruited patients diagnosed with IIH and healthy controls. A lumbar puncture was performed for ICP measurement. All the participants underwent OCT examinations. The choroid was automatically segmented and imaged by the OCT tool. The parafoveal choroidal vascular volume (CVV) and choroidal vascular index (CVI) were calculated in 3 mm annulus and 6 mm annulus. Results A total of 80 patients with IIH (34.67 ± 11.00 years; 37.50% males) and 92 controls (34.50 ± 12.08 years; 36.96% males) were included in the final analysis. Patients with IIH had higher BMI (< 0.001) and poor visual acuity (< 0.001) compared with controls. Patients with IIH demonstrated significantly lower parafovea CVI in both annuluses (p = 0.003 for 3 mm annulus, p = 0.001 for 6 mm annulus) compared to controls. Mean parafovea CVI in both annuluses was significantly correlated with ICP level (p = 0.014 for 3 mm annulus, p = 0.015 for 6 mm annulus). The combination of CVV and CVI in a 6 mm annulus demonstrated the highest diagnostic value with a mean AUC of 0.818. Conclusion CVI may serve as a potential marker for identifying IIH and reflecting ICP changes.https://doi.org/10.1002/brb3.70258choroidal vascular indexidiopathic intracranial hypertensionswept‐source optical coherence tomography |
| spellingShingle | Hang Wang Rui Wang Le Cao William Robert Kwapong Ruishan Liu Fayun Hu Bo Wu Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension Brain and Behavior choroidal vascular index idiopathic intracranial hypertension swept‐source optical coherence tomography |
| title | Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension |
| title_full | Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension |
| title_fullStr | Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension |
| title_full_unstemmed | Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension |
| title_short | Decreased Choroidal Vascular Index in Idiopathic Intracranial Hypertension |
| title_sort | decreased choroidal vascular index in idiopathic intracranial hypertension |
| topic | choroidal vascular index idiopathic intracranial hypertension swept‐source optical coherence tomography |
| url | https://doi.org/10.1002/brb3.70258 |
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